Gene Report

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Basic Info

Approved Symbol	TAAR1
Previous Symbol	TRAR1
Symbol Alias	TAR1, TA1
Approved Name	trace amine associated receptor 1
Previous Name	trace amine receptor 1
Location	6q23.1
Position	chr6:132644984-132646003, -1
External Links	HGNC: 17734 Entrez Gene: 134864 Ensembl: ENSG00000146399 UCSC: uc003qdm.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Abou Jamra, R.,2005(b)	SNP: rs8192620	We observed no significant TDT results in TRAR1.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005887	integral component of plasma membrane	cellular component	IBA	158
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0016021	integral component of membrane	cellular component	IC[15718104]	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[15718104]	64
GO:0007606	sensory perception of chemical stimulus	biological process	IBA	14
GO:0001594	trace-amine receptor activity	molecular function	IBA	4
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway	biological process	IBA	16
GO:0004930	G-protein coupled receptor activity	molecular function	TAS[15718104]	26
GO:0006171	cAMP biosynthetic process	biological process	IDA[11723224]	6

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 9)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs8192620	chr6:132645140 - 132645140(1)	synonymous_variant	1(0/1/0)
rs9389020	chr6:132641914 - 132641914(1)	downstream_gene_variant	1(0/1/0)
rs9402439	chr6:132646463 - 132646463(1)	upstream_gene_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs6569819	chr6:132641902 - 132641902(1)	downstream_gene_variant
rs9375906	chr6:132644536 - 132644536(1)	downstream_gene_variant
rs9375907	chr6:132644904 - 132644904(1)	downstream_gene_variant
rs7764501	chr6:132643697 - 132643697(1)	downstream_gene_variant
rs9389021	chr6:132642416 - 132642416(1)	downstream_gene_variant
rs12211535	chr6:132643555 - 132643555(1)	downstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q23	chr6:130000000-138300000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
17505468	516	Negative

Gene relationship with MDD

View in gBrowse

Region: chr6:132644984..132646003 View in gBrowse