Gene Report

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Basic Info

Approved Symbol	PTGFR
Symbol Alias	FP
Approved Name	prostaglandin F receptor (FP)
Location	1p31.1
Position	chr1:78303884-78539749, 1
External Links	HGNC: 9600 Entrez Gene: 5737 Ensembl: ENSG00000122420 UCSC: uc001din.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, D. T.,2011	SNP: rs4650608	The results suggest novel association findings near the gene.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IDA[18508192]; TAS	360
GO:0005887	integral component of plasma membrane	cellular component	TAS[8300593]	158

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004958	prostaglandin F receptor activity	molecular function	IDA[18587449]	1
GO:0005576	extracellular region	cellular component	IDA[10575000]	97
GO:0032496	response to lipopolysaccharide	biological process	IEA	22
GO:0008284	positive regulation of cell proliferation	biological process	IMP[18508192]	44
GO:0007567	parturition	biological process	TAS[9918852]	3
GO:0071799	cellular response to prostaglandin D stimulus	biological process	IMP[18508192]	1
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IEA	64
GO:0035584	calcium-mediated signaling using intracellular calcium source	biological process	IDA[18587449]	4
GO:0043066	negative regulation of apoptotic process	biological process	IEA	46
GO:0005737	cytoplasm	cellular component	IDA[18508192]	322

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04020	Calcium signaling pathway	53

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PTGFR	PTGDS	NO	in vivo	8300593
PTGFR	PTGES2	NO	in vivo	8300593
PTGFR	PTGER1	NO	in vivo	8253813
PTGFR	PTGER2	NO	in vivo	8163486

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4650608	chr1:78772330 - 78772330(1)		3(2/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p32.1-q31.1	chr1:58500000-190800000	1 (0/1/0)
1p31.1-p22.1	chr1:69300000-94300000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)
1p31.1	chr1:69300000-84400000	0

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:78303884..78539749 View in gBrowse