Gene Report

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Basic Info

Approved Symbol	SPRED1
Symbol Alias	FLJ33903, PPP1R147
Approved Name	sprouty-related, EVH1 domain containing 1
Name Alias	protein phosphatase 1, regulatory subunit 147
Location	15q14
Position	chr15:38252326-38357249, 1
External Links	HGNC: 20249 Entrez Gene: 161742 Ensembl: ENSG00000166068 UCSC: uc001zka.4
No. of Studies	2 (Positive: 0; Negative: 1; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Sklar, P.,2011	SNP: rs16966413	No significant association was observed.	Negative	Comment on Study
Green, E. K.,2012	SNP: rs16966413	BD ImmunoChip:P-value = 0.015,OR = 0.824;ImmunoChip, PGC-BD combined data:P-balue = 0.00000593,OR = 0.872 Suggestive association was found.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007275	multicellular organismal development	biological process	IEA	24

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005901	caveola	cellular component	IEA	11
GO:0010923	negative regulation of phosphatase activity	biological process	IDA[19389623]	5
GO:0005173	stem cell factor receptor binding	molecular function	ISS	1
GO:0090311	regulation of protein deacetylation	biological process	ISS[20736167]	1
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0005515	protein binding	molecular function	IPI[15231748]	563
GO:0019902	phosphatase binding	molecular function	IDA[19389623]	9
GO:0010801	negative regulation of peptidyl-threonine phosphorylation	biological process	IMP[20736167]	1
GO:0030291	protein serine/threonine kinase inhibitor activity	molecular function	ISS[20736167]	1
GO:0000188	inactivation of MAPK activity	biological process	ISS	3
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	biological process	ISS[20736167]	3
GO:0019901	protein kinase binding	molecular function	IPI[20736167]	29

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04630	Jak-STAT signaling pathway	14

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SPRED1	PPP1CA	NO	yeast 2-hybrid	15231748
SPRED1	KIT	NO	in vitro	12646235

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs16966413	chr15:38187698 - 38187698(1)	intron_variant; non_coding_transcript_variant	2(0/1/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 15	chr15:0-101991189	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr15:38252326..38357249 View in gBrowse