Gene Report

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Basic Info

Approved Symbol	NEK5
Approved Name	NIMA-related kinase 5
Previous Name	NIMA (never in mitosis gene a)-related kinase 5
Location	13q14.2
Position	chr13:52033611-52129078, -1
External Links	HGNC: 7748 Entrez Gene: 341676 Ensembl: ENSG00000197168 UCSC: uc001vge.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Strauss, K. A., 2014	SNP: rs34756139	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004674	protein serine/threonine kinase activity	molecular function	IBA	27
GO:0005634	nucleus	cellular component	IBA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:2001056	positive regulation of cysteine-type endopeptidase activity	biological process	IEA	1
GO:0005524	ATP binding	molecular function	IEA	118
GO:0006468	protein phosphorylation	biological process	IBA	42
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0051155	positive regulation of striated muscle cell differentiation	biological process	IEA	2

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs34756139	chr13:52102139 - 52102139(1)	missense_variant; NMD_transcript_variant	1(0/1/0)
rs3742290	chr13:52029105 - 52029105(1)	3_prime_UTR_variant; downstream_gene_variant; missense_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
13q12-14	chr13:18900000-54700000	1 (0/1/0)
13q14	chr13:39500000-54700000	3 (0/1/2)
13q13-q14	chr13:31600000-54700000	1 (1/0/0)
Chr 13	chr13:0-114364328	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr13:52033611..52129078 View in gBrowse