Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	MTMR3
Symbol Alias	KIAA0371, ZFYVE10, FYVE-DSP1
Approved Name	myotubularin related protein 3
Location	22q12.2
Position	chr22:29883155-30030866, 1
External Links	HGNC: 7451 Entrez Gene: 8897 Ensembl: ENSG00000100330 UCSC: uc003agv.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs11090591	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016020	membrane	cellular component	IDA[10733931]	137

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0035335	peptidyl-tyrosine dephosphorylation	biological process	IDA[10733931]; IEA	9
GO:0046856	phosphatidylinositol dephosphorylation	biological process	IDA[10900271]	2
GO:0004438	phosphatidylinositol-3-phosphatase activity	molecular function	IDA[10900271]	2
GO:0006470	protein dephosphorylation	biological process	IDA[10733931]	10
GO:0006644	phospholipid metabolic process	biological process	TAS	18
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0004722	protein serine/threonine phosphatase activity	molecular function	IDA[10733931]	4
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0019898	extrinsic component of membrane	cellular component	IDA[11676921]	8
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0004725	protein tyrosine phosphatase activity	molecular function	IDA[10733931]	6
GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	molecular function	IDA[11676921]	1
GO:0005829	cytosol	cellular component	TAS	223
GO:0006661	phosphatidylinositol biosynthetic process	biological process	TAS	13
GO:0046872	metal ion binding	molecular function	IEA	115

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 22)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs11090591	chr22:29981324 - 29981324(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(0/1/0)

LD-proxies (count: 21)

rs_ID	Location	Functional Annotation
rs17644868	chr22:29935509 - 29935509(1)	intron_variant; non_coding_transcript_variant
rs9625886	chr22:29923760 - 29923760(1)	intron_variant; non_coding_transcript_variant
rs3788418	chr22:29884173 - 29884173(1)	intron_variant; non_coding_transcript_variant
rs17713646	chr22:29979976 - 29979976(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs737907	chr22:29978931 - 29978931(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; splice_region_variant
rs737906	chr22:29971868 - 29971868(1)	intron_variant; non_coding_transcript_variant
rs737905	chr22:29971501 - 29971501(1)	intron_variant; non_coding_transcript_variant
rs11705207	chr22:29964999 - 29964999(1)	intron_variant; non_coding_transcript_variant
rs11704885	chr22:29964815 - 29964815(1)	intron_variant; non_coding_transcript_variant
rs12166755	chr22:29948182 - 29948182(1)	intron_variant; non_coding_transcript_variant
rs17644886	chr22:29935564 - 29935564(1)	intron_variant; non_coding_transcript_variant
rs12165769	chr22:30003011 - 30003011(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs3788425	chr22:30004712 - 30004712(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs12169823	chr22:29994665 - 29994665(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs9620936	chr22:29997837 - 29997837(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs11090592	chr22:29983872 - 29983872(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs9620935	chr22:29984539 - 29984539(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs9625895	chr22:29980012 - 29980012(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs9625896	chr22:29980025 - 29980025(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs17647135	chr22:30016770 - 30016770(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs12330007	chr22:30033675 - 30033675(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 22	chr22:0-50818468	2 (0/1/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr22:29883155..30030866 View in gBrowse