Gene Report

Approved Symbol	KCNQ3
Previous Symbol	EBN2
Symbol Alias	Kv7.3
Approved Name	potassium channel, voltage gated KQT-like subfamily Q, member 3
Previous Name	potassium voltage-gated channel, KQT-like subfamily, member 3
Location	8q24
Position	chr8:132120859-132480953, -1
External Links	HGNC: 6297 Entrez Gene: 3786 Ensembl: ENSG00000184156 UCSC: uc003ytj.3
No. of Studies	4 (Positive: 3; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Koefoed, P.,2011	SNP: rs2469515	KCNQ3_rs2469515=2)occurred in 32 3-combinations.In 1000 permutation tests, at least one cluster of this type (with at least 37 pseudo-patients) were seen 42 times (p=0.042), two such clusters were seen 3 times (p=0.003), and at least three or more clusters of this type did not occur once(p<0.001).. The present analyses of the combinations of SNP genotypes support a role for both genetic heterogeneity and interactions in the genetic architecture of bipolar disorder.	Positive	Comment on Study
de Mooij-van Malsen, A. J.,2009		Within the basic control dataset, a significant association was found for KCNQ3 (rs1437812; P-value = 0.0029; additive model, without sex-stratification).	Positive	Comment on Study
Zhang, P.,2010	SNP: rs17602731, rs2673582, rs6984550	Our association results showed suggestive evidence of association of BP with loci near KCNQ3.	Trend	Comment on Study
Zandi, P. P., 2007	Haplotype: rs2673555 - rs1901090()	rs1901090 in the KCNQ3 gene was nominally (P<0.05) significant in the single SNP analysis. A two-SNP haplotype in KCNQ3 (rs2673555-rs1901090) was associated at P=0.003.	Positive	Comment on Study

Region: chr8:132120859..132480953 View in gBrowse