Gene Report

Basic Info
Approved Symbol KCNQ3
Previous Symbol EBN2
Symbol Alias Kv7.3
Approved Name potassium channel, voltage gated KQT-like subfamily Q, member 3
Previous Name potassium voltage-gated channel, KQT-like subfamily, member 3
Location 8q24
Position chr8:132120859-132480953, -1
External Links HGNC: 6297
Entrez Gene: 3786
Ensembl: ENSG00000184156
UCSC: uc003ytj.3
No. of Studies 4 (Positive: 3; Negative: 0; trend: 1)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 4)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Koefoed, P.,2011 SNP: rs2469515 KCNQ3_rs2469515=2)occurred in 32 3-combinations.In 1000 permutation tests, at least one cluster of this type (with at least 37 pseudo-patients) were seen 42 times (p=0.042), two such clusters were seen 3 times (p=0.003), and at least three or more clusters of this type did not occur once(p<0.001).. The present analyses of the combinations of SNP genotypes support a role for both genetic heterogeneity and interactions in the genetic architecture of bipolar disorder. Positive Comment on Study
de Mooij-van Malsen, A. J.,2009 Within the basic control dataset, a significant association was found for KCNQ3 (rs1437812; P-value = 0.0029; additive model, without sex-stratification). Positive Comment on Study
Zhang, P.,2010 SNP: rs17602731, rs2673582, rs6984550 Our association results showed suggestive evidence of association of BP with loci near KCNQ3. Trend Comment on Study
Zandi, P. P., 2007 Haplotype: rs2673555 - rs1901090() rs1901090 in the KCNQ3 gene was nominally (P<0.05) significant in the single SNP analysis. A two-SNP haplotype in KCNQ3 (rs2673555-rs1901090) was associated at P=0.003. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 14)

GO terms by PBA (count: 9)

GO terms by database search (count: 5)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Related other genetic factors
Gene related SNPs (count: 7)

Literature-origin SNPs (count: 4)

LD-proxies (count: 3)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr8:132120859..132480953 View in gBrowse
View in gBrowse