Gene Report

Basic Info
Approved Symbol ERBB4
Symbol Alias ALS19, HER4
Approved Name erb-b2 receptor tyrosine kinase 4
Previous Name v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4, "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4"
Name Alias human epidermal growth factor receptor 4
Location 2q33.3-q34
Position chr2:211375717-212538841, -1
External Links HGNC: 3432
Entrez Gene: 2066
Ensembl: ENSG00000178568
UCSC: uc002veg.1
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Chen, P.,2012 SNP: rs10207288, rs2371276, rs707284, rs839511, rs839523 In summary, we found no evidence that ErbB4 was associated with the three major psychiatric disorders in our Chinese population sample. Negative Comment on Study
Goes, F. S.,2011 Other variant: ERBB4_SNV8_A insertion/deletion, ERBB4_SNV7_G>A In conclusion, we found no rare variants of clear deleterious effect, but did uncover a modestly associated novel variant that could affect alternative splicing of ERBB4. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 55)

GO terms by PBA (count: 8)

GO terms by database search (count: 47)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 2)

Gene related interactors from protein-protein interactions data in HPRD (count: 25)

Related other genetic factors
Gene related SNPs (count: 71)

Literature-origin SNPs (count: 5)

LD-proxies (count: 66)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Gene related regions (count: 1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 10)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr2:211375717..212538841 View in gBrowse
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