Gene Report

Basic Info
Approved Symbol DLG2
Symbol Alias PSD-93, PSD93, chapsyn-110, PPP1R58
Approved Name discs, large homolog 2 (Drosophila)
Previous Name discs, large homolog 2, chapsyn-110 (Drosophila)
Name Alias protein phosphatase 1, regulatory subunit 58
Location 11q21
Position chr11:83455012-85627922, -1
External Links HGNC: 2901
Entrez Gene: 1740
Ensembl: ENSG00000150672
UCSC: uc001pak.2
No. of Studies 3 (Positive: 1; Negative: 1; trend: 1)
Overlap with SZ? NO
Overlap with MDD? YES
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Georgieva, L., 2014 The more likely candidate loci is in this gene. Trend Comment on Study
Noor A., 2014 Two deletions and one duplication involving the post-synaptic density gene DLG2 were detected and validated in three unrelated cases. Positive Comment on Study
Xu, W., 2014 SNP: rs1893050 The SNP within or near this gene did not achieve genome-wide significance. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 20)

GO terms by PBA (count: 6)

GO terms by database search (count: 14)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 29)

Related other genetic factors
Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

LD-proxies (count: 0)

Gene related CNVs (count: 3)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

View in gBrowse

Region: chr11:83455012..85627922 View in gBrowse
View in gBrowse