Gene Report

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Basic Info

Approved Symbol	DLG2
Symbol Alias	PSD-93, PSD93, chapsyn-110, PPP1R58
Approved Name	discs, large homolog 2 (Drosophila)
Previous Name	discs, large homolog 2, chapsyn-110 (Drosophila)
Name Alias	protein phosphatase 1, regulatory subunit 58
Location	11q21
Position	chr11:83455012-85627922, -1
External Links	HGNC: 2901 Entrez Gene: 1740 Ensembl: ENSG00000150672 UCSC: uc001pak.2
No. of Studies	3 (Positive: 1; Negative: 1; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 3)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgieva, L., 2014		The more likely candidate loci is in this gene.	Trend	Comment on Study
Noor A., 2014		Two deletions and one duplication involving the post-synaptic density gene DLG2 were detected and validated in three unrelated cases.	Positive	Comment on Study
Xu, W., 2014	SNP: rs1893050	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045211	postsynaptic membrane	cellular component	IBA	68
GO:0005886	plasma membrane	cellular component	TAS[8755482]	360
GO:0007268	synaptic transmission	biological process	IBA	116
GO:0016020	membrane	cellular component	ISS	137
GO:0008076	voltage-gated potassium channel complex	cellular component	ISS	8
GO:0007399	nervous system development	biological process	IBA	40

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0010923	negative regulation of phosphatase activity	biological process	IDA[19389623]	5
GO:0016323	basolateral plasma membrane	cellular component	IBA	21
GO:0046939	nucleotide phosphorylation	biological process	TAS[8755482]	3
GO:0005515	protein binding	molecular function	IPI[15304517]	563
GO:0014069	postsynaptic density	cellular component	IBA	26
GO:0097120	receptor localization to synapse	biological process	IBA	5
GO:0043113	receptor clustering	biological process	IBA	8
GO:0019233	sensory perception of pain	biological process	IEA	15
GO:0004385	guanylate kinase activity	molecular function	TAS[8755482]	3
GO:0008328	ionotropic glutamate receptor complex	cellular component	IBA	6
GO:0030054	cell junction	cellular component	IEA	88
GO:0044224	juxtaparanode region of axon	cellular component	ISS	1
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	biological process	IBA	3
GO:0035255	ionotropic glutamate receptor binding	molecular function	IBA	8

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 29)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DLG2	GUCY1A2	NO	in vitro	11572861
DLG2	LRP2	NO	in vitro;yeast 2-hybrid	12713445
DLG2	CNKSR2	NO	in vitro	16637659
DLG2	ATP2B4	NO	in vitro;in vivo	11274188
DLG2	WNT3A	NO	yeast 2-hybrid	12067714
DLG2	DLGAP1	YES	yeast 2-hybrid	11122378
DLG2	GRID2	NO	in vivo;yeast 2-hybrid	10234023
DLG2	KCNJ4	NO	in vitro	11997254
DLG2	FZD4	NO	yeast 2-hybrid	12067714
DLG2	GRIN2D	YES	in vivo	10862698
DLG2	LIN7A	NO	in vitro	9753324
DLG2	FZD7	NO	yeast 2-hybrid	12067714
DLG2	NLGN3	NO	yeast 2-hybrid	9278515
DLG2	FZD1	NO	yeast 2-hybrid	12067714
DLG2	GLS2	NO	in vitro	16637659
DLG2	MAP1A	NO	in vivo	9786987
DLG2	SEMA4C	NO	in vitro;in vivo;yeast 2-hybrid	11134026
DLG2	CRIPT	NO	in vitro;in vivo;yeast 2-hybrid	9581762 , 12070168
DLG2	DLG4	NO	in vivo	9182804
DLG2	SCN5A	NO	in vitro	16637659
DLG2	ABCA1	YES	in vitro	16192276
DLG2	KIF1B	NO	in vitro	16637659
DLG2	KCNJ12	NO	in vitro;in vivo	15024025
DLG2	KCNJ2	NO	in vitro;yeast 2-hybrid	15304517
DLG2	SCN4A	NO	in vitro	16637659
DLG2	MAPK12	NO	in vitro	16637659
DLG2	KCNA4	NO	in vitro	11997254
DLG2	ATP2B2	NO	in vitro;in vivo	11274188
DLG2	GRIN1	YES	in vivo	10862698

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1893050	chr11:84917050 - 84917050(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)

Gene related CNVs (count: 3)

ID	Location	Size	Band	Type
CNV_Abdul Noor[2014]_15	chr11:83821345-83990370 (NCBI Build 36/hg18)	169000	11q14.1	deletion
CNV_Abdul Noor[2014]_16	chr11:83789032-84032216 (NCBI Build 36/hg18)	243000	11q14.1	deletion
CNV_Lyudmila Georgieva[2014]_7	chr11:84139937-84345829 (UCSC build 37, hg19)	205892	11q14.1	deletion

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
11q14.1	chr11:77400000-85900000	2 (1/0/1)
11q14.1-14.3	chr11:77400000-93000000	1 (0/1/0)
11q14-q21	chr11:77100000-92800000	1 (0/1/0)
Chr 11	chr11:0-135086622	2 (0/2/0)
11q14.3-11q21	chr11:22000000-97400000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
22339950	Our findings demonstrate significant dysregulation of synaptic function/structure related genes SNAP25, DLG2 (SAP93), and MAP1A, and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid receptor subunit genes GLUR1 and GLUR3	Pos	DLG2

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Region: chr11:83455012..85627922 View in gBrowse