Gene Report

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Basic Info

Approved Symbol	ADAMTSL3
Symbol Alias	KIAA1233, punctin-2
Approved Name	ADAMTS-like 3
Location	15q25.2
Position	chr15:83654086-84039842, 1
External Links	HGNC: 14633 Entrez Gene: 57188 Ensembl: ENSG00000156218 UCSC: uc002bjz.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0030. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008237	metallopeptidase activity	molecular function	IEA	8

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006508	proteolysis	biological process	IEA	34
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0005578	proteinaceous extracellular matrix	cellular component	IEA	19
GO:0008270	zinc ion binding	molecular function	IEA	77

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
15q25-26	chr15:78000000-101991189	1 (1/0/0)
15q24.1-25.2	chr15:72400000-84700000	1 (0/1/0)
Chr 15	chr15:0-101991189	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr15:83654086..84039842 View in gBrowse