Gene Report

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Basic Info

Approved Symbol	HNRNPC
Previous Symbol	HNRPC
Symbol Alias	hnRNPC
Approved Name	heterogeneous nuclear ribonucleoprotein C (C1/C2)
Location	14q11.2
Position	chr14:21209136-21269494, -1
External Links	HGNC: 5035 Entrez Gene: 3183 Ensembl: ENSG00000092199 UCSC: uc001waa.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Smith, E. N.,2011	SNP: rs17197037	No significant association of this gene was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008380	RNA splicing	biological process	TAS	8
GO:0005634	nucleus	cellular component	IDA[21630459]	283
GO:0003730	mRNA 3'-UTR binding	molecular function	IDA[16010978]	4
GO:0000398	mRNA splicing, via spliceosome	biological process	IC[11991638]; TAS	6
GO:0016020	membrane	cellular component	IDA[16210410]	137

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0010467	gene expression	biological process	TAS	41
GO:0005681	spliceosomal complex	cellular component	IDA[9731529]	6
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674]	44
GO:0000166	nucleotide binding	molecular function	IEA	17
GO:0000790	nuclear chromatin	cellular component	IDA[16217013]	7
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	molecular function	IDA[16217013]	23
GO:0005829	cytosol	cellular component	IDA[16010978]	223
GO:0003723	RNA binding	molecular function	NAS[9731529]	14
GO:0005515	protein binding	molecular function	IPI[15161933]	563
GO:0070935	3'-UTR-mediated mRNA stabilization	biological process	IMP[16010978]	1
GO:0001649	osteoblast differentiation	biological process	IDA[16210410]	9
GO:0043044	ATP-dependent chromatin remodeling	biological process	IDA[16217013]	1
GO:0008266	poly(U) RNA binding	molecular function	IDA[16010978]	2
GO:0071013	catalytic step 2 spliceosome	cellular component	IDA[11991638]	4
GO:0043234	protein complex	cellular component	IDA[16217013]	27
GO:0070062	extracellular vesicular exosome	cellular component	IDA[20458337]	176
GO:0031492	nucleosomal DNA binding	molecular function	IDA[16217013]	1
GO:0042802	identical protein binding	molecular function	IPI[16189514]	44
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	molecular function	IDA[16217013]	5

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 18)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
HNRNPC	ZNF581	NO	yeast 2-hybrid	16189514
HNRNPC	SFRS12	NO	in vitro;in vivo;yeast 2-hybrid	14559993
HNRNPC	CSNK1A1	NO	in vitro	15687492
HNRNPC	PHKB	NO	yeast 2-hybrid	16189514
HNRNPC	KPNA3	NO	yeast 2-hybrid	16189514
HNRNPC	CCDC85B	NO	yeast 2-hybrid	16189514
HNRNPC	UBE2I	NO	yeast 2-hybrid	16189514
HNRNPC	DHX9	NO	in vivo	15034300
HNRNPC	PDGFB	YES	in vitro	10409733
HNRNPC	GRB2	NO	in vitro;in vivo	9516488
HNRNPC	RBM41	NO	yeast 2-hybrid	16189514
HNRNPC	KRAS	NO	yeast 2-hybrid	16189514
HNRNPC	PIN1	NO	yeast 2-hybrid	16189514
HNRNPC	FXR2	NO	yeast 2-hybrid	16189514
HNRNPC	RALYL	NO	yeast 2-hybrid	16189514
HNRNPC	AP1M1	NO	yeast 2-hybrid	16189514
HNRNPC	LMO3	YES	yeast 2-hybrid	16189514
HNRNPC	CSNK2A2	NO	in vitro;in vivo	12564933

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs17197037	chr14:21257495 - 21257495(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q11.2	chr14:18200000-24100000	1 (0/0/1)
Chr 14	chr14:0-107043718	2 (0/2/0)
14q11.2-12.0	chr14:18200000-32900000	1 (0/1/0)
14q11.2-14q12	chr14:18200000-32900000	1 (0/0/1)
14q11.2-q13.1	chr14:18200000-34800000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr14:21209136..21269494 View in gBrowse