Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	MMP16
Previous Symbol	C8orf57
Symbol Alias	MT3-MMP, DKFZp761D112
Approved Name	matrix metallopeptidase 16 (membrane-inserted)
Previous Name	matrix metalloproteinase 16 (membrane-inserted), "chromosome 8 open reading frame 57"
Location	8q21
Position	chr8:88032009-88328025, -1
External Links	HGNC: 7162 Entrez Gene: 4325 Ensembl: ENSG00000156103 UCSC: uc003yeb.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Saito T., 2014	SNP: rs7004633	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005887	integral component of plasma membrane	cellular component	TAS[7559440]	158
GO:0004222	metalloendopeptidase activity	molecular function	IEA	8
GO:0005509	calcium ion binding	molecular function	IEA	50
GO:0001958	endochondral ossification	biological process	IEA	3

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005578	proteinaceous extracellular matrix	cellular component	IEA	19
GO:0009986	cell surface	cellular component	IEA	40
GO:0006508	proteolysis	biological process	IEA	34
GO:0008047	enzyme activator activity	molecular function	TAS[7559440]	3
GO:0030198	extracellular matrix organization	biological process	TAS	26
GO:0022617	extracellular matrix disassembly	biological process	TAS	10
GO:0005796	Golgi lumen	cellular component	TAS	9
GO:0043085	positive regulation of catalytic activity	biological process	TAS[7559440]	4
GO:0030574	collagen catabolic process	biological process	IEA	4
GO:0048701	embryonic cranial skeleton morphogenesis	biological process	IEA	3
GO:0097094	craniofacial suture morphogenesis	biological process	IEA	1
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0035988	chondrocyte proliferation	biological process	IEA	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
MMP16	KISS1	NO	in vitro;in vivo	12879005
MMP16	LRP1	NO	in vitro	14645246

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7004633	chr8:88748082 - 88748082(1)		2(1/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8q12.1-q22.1	chr8:54600000-97900000	1 (1/0/0)
Chr 8	chr8:0-145138636	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
24888570	The associated SNP in this gene showed significant association with SZ.	Positive

Gene relationship with MDD

View in gBrowse

Region: chr8:88032009..88328025 View in gBrowse