Gene Report

Basic Info
Approved Symbol GRIN2D
Previous Symbol NMDAR2D
Symbol Alias GluN2D, EB11, NR2D
Approved Name glutamate receptor, ionotropic, N-methyl D-aspartate 2D
Name Alias N-methyl-d-aspartate receptor subunit 2D
Location 19q13.33
Position chr19:48394875-48444931, 1
External Links HGNC: 4588
Entrez Gene: 2906
Ensembl: ENSG00000105464
UCSC: uc002pjc.4
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Shi, J., 2008 (b) SNP: rs1799281 rs1799281 in the GRIN2D gene reached gene-wide association (permutation P<0.05 for all SNPs of each gene). . None of these associations survived multiple testing for its own system (e.g., glutamatergic or serotoninergic) or all the five systems taken together (permutation adjusted P>0.05)。 Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 16)

GO terms by PBA (count: 4)

GO terms by database search (count: 12)

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 2)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 25)

Related other genetic factors
Gene related SNPs (count: 2)

Literature-origin SNPs (count: 1)

LD-proxies (count: 1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

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Region: chr19:48394875..48444931 View in gBrowse
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