Gene Report

Basic Info
Approved Symbol XRCC4
Approved Name X-ray repair complementing defective repair in Chinese hamster cells 4
Name Alias X-ray repair, complementing defective, repair in Chinese hamster, "DNA repair protein XRCC4"
Location 5q14.2
Position chr5:83077498-83353787, 1
External Links HGNC: 12831
Entrez Gene: 7518
Ensembl: ENSG00000152422
UCSC: uc003kib.3
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kazemi-Noughabi, M., 2016 SNP: rs28360071 The association between the XRCC4 Ins/Del polymorphism and the risk of BPI was not significant either in Ins/Del (odds ratio=1.20, 95% confidence interval=0.79-1.83, P=0.394) or in Del/Del (odds ratio=1.20, 95% confidence interval=0.69-2.07,P=0.515) genotypes compared with the Ins/Ins genotype. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 32)

GO terms by PBA (count: 4)

GO terms by database search (count: 28)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 15)

Related other genetic factors
Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr5:83077498..83353787 View in gBrowse
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