Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	ADRA2C
Previous Symbol	ADRA2L2, ADRA2RL2
Symbol Alias	ADRARL2
Approved Name	adrenoceptor alpha 2C
Previous Name	adrenergic, alpha-2C-, receptor
Location	4p16.3
Position	chr4:3766348-3768526, 1
External Links	HGNC: 283 Entrez Gene: 152 Ensembl: ENSG00000184160 UCSC: uc003ghm.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Abou Jamra, R., 2004	Other variant: ADRA2C_5'UTR_(GT)n	We observed no significant differences in transmissions for any of the genetic variants in the three ADRA genes.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 28)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0007565	female pregnancy	biological process	IEA	15
GO:0005887	integral component of plasma membrane	cellular component	IDA[16605244]	158

GO terms by database search (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0035625	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	biological process	IDA[17215105]	2
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[9371698]	64
GO:0046982	protein heterodimerization activity	molecular function	IPI[16605244]	42
GO:0031694	alpha-2A adrenergic receptor binding	molecular function	IPI[16605244]	1
GO:0007267	cell-cell signaling	biological process	TAS[9371698]	29
GO:0004938	alpha2-adrenergic receptor activity	molecular function	IDA[17215105]	2
GO:0006112	energy reserve metabolic process	biological process	TAS	19
GO:0030168	platelet activation	biological process	TAS	22
GO:0043679	axon terminus	cellular component	IEA	8
GO:0042803	protein homodimerization activity	molecular function	IDA[16605244]	71
GO:0070473	negative regulation of uterine smooth muscle contraction	biological process	IEA	2
GO:0007596	blood coagulation	biological process	TAS	44
GO:0032811	negative regulation of epinephrine secretion	biological process	NAS[16531006]	4
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0051379	epinephrine binding	molecular function	IDA[17215105]	2
GO:0045666	positive regulation of neuron differentiation	biological process	IDA[17215105]	8
GO:0032148	activation of protein kinase B activity	biological process	IDA[17215105]	5
GO:0045907	positive regulation of vasoconstriction	biological process	IEA	12
GO:0005515	protein binding	molecular function	IPI[16531006]	563
GO:0051930	regulation of sensory perception of pain	biological process	IEA	7
GO:0005768	endosome	cellular component	TAS[10196213]	27
GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway	biological process	IDA[17215105]	2
GO:0050796	regulation of insulin secretion	biological process	TAS	24
GO:0005737	cytoplasm	cellular component	IDA[16605244]	322
GO:0010700	negative regulation of norepinephrine secretion	biological process	NAS[16531006]; TAS[19477270]	3

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ADRA2C	YWHAZ	NO	in vitro	10224112
ADRA2C	GNAO1	NO	in vivo	1349607
ADRA2C	EIF2B1	NO	in vitro;in vivo	9235896

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
ADRA2C_5'UTR_(GT)n	microsatellite	5' UTR	1 (0/1/0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
4p16.3	chr4:0-4500000	1 (1/0/0)
Chr 4	chr4:0-190214555	3 (0/3/0)
4p16	chr4:0-11300000	2 (0/1/1)
4p	chr4:0-50000000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr4:3766348..3768526 View in gBrowse