Gene Report

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Basic Info

Approved Symbol	CDK13
Previous Symbol	CDC2L5
Symbol Alias	CHED, CDC2L, KIAA1791
Approved Name	cyclin-dependent kinase 13
Previous Name	cell division cycle 2-like 5 (cholinesterase-related cell division controller)
Name Alias	cholinesterase-related cell division controller
Location	7p14.1
Position	chr7:39950037-40097134, 1
External Links	HGNC: 1733 Entrez Gene: 8621 Ensembl: ENSG00000065883 UCSC: uc003thh.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, X., 2015		CDK13 has been implicated in autism spectrum disorders.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004672	protein kinase activity	molecular function	TAS[1731328]	13
GO:0007275	multicellular organismal development	biological process	TAS[1731328]	24

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005515	protein binding	molecular function	IPI[16721827]	563
GO:0016032	viral process	biological process	IEA	26
GO:0005524	ATP binding	molecular function	IEA	118
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	molecular function	IEA	1
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	molecular function	IDA[20952539]	1
GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	biological process	IDA[20952539]	1
GO:0007088	regulation of mitotic nuclear division	biological process	TAS[1731328]	1
GO:0016607	nuclear speck	cellular component	IDA[16721827]	16
GO:0005615	extracellular space	cellular component	IDA[22664934]	85
GO:0008284	positive regulation of cell proliferation	biological process	TAS[1731328]	44
GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex	cellular component	ISS	1
GO:0030332	cyclin binding	molecular function	IPI[22012619]	2
GO:0000380	alternative mRNA splicing, via spliceosome	biological process	ISS; TAS[16721827]	3
GO:0044822	poly(A) RNA binding	molecular function	IDA[22681889]	44
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0030097	hemopoiesis	biological process	IMP[1731328]	7
GO:0005794	Golgi apparatus	cellular component	IDA	60
GO:0002945	cyclin K-CDK13 complex	cellular component	IPI[22012619]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CDK13	PRPF40A	NO	yeast 2-hybrid	15231748
CDK13	CHMP4A	NO	yeast 2-hybrid	16730941

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 7	chr7:0-159345973	3 (0/3/0)
7p15-q21	chr7:20900000-98400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:39950037..40097134 View in gBrowse