Gene Report

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Basic Info

Approved Symbol	RTN4R
Symbol Alias	NOGOR
Approved Name	reticulon 4 receptor
Location	22q11
Position	chr22:20241415-20283246, -1
External Links	HGNC: 18601 Entrez Gene: 65078 Ensembl: ENSG00000040608 UCSC: uc002zrv.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		4 SNP typed, Median D'=0.69, Median r<sup>2</sup> =0.42, 2 LD blocks, 0.07 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004872	receptor activity	molecular function	NAS[11201742]	19
GO:0005886	plasma membrane	cellular component	TAS	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23533145]	176
GO:0050770	regulation of axonogenesis	biological process	TAS	7
GO:0007409	axonogenesis	biological process	NAS[11201742]	11
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	33
GO:0005515	protein binding	molecular function	IPI[20463223]	563
GO:0031225	anchored component of membrane	cellular component	IEA	11
GO:0030426	growth cone	cellular component	IEA	22
GO:0009986	cell surface	cellular component	IDA[20463223]	40
GO:0050771	negative regulation of axonogenesis	biological process	TAS	5
GO:0005783	endoplasmic reticulum	cellular component	IDA	49

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
RTN4R	NGFR	NO	in vitro;in vivo	12422217
RTN4R	RTN4IP1	NO	in vitro	12160746
RTN4R	MAG	NO	in vitro;in vivo	12160746 , 12089450
RTN4R	LINGO1	NO	in vitro;in vivo	14966521
RTN4R	RTN4	YES	in vivo	11201742

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Zhang[2009]_306	chr22:17386126-18691917 (Affymetrix SNP 6.0 array reference genome)	1305791		Singleton deletions

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
22q11	chr22:15000000-25500000	1 (0/1/0)
22q11.2	chr22:17400000-25500000	2 (0/2/0)
Chr 22	chr22:0-50818468	2 (0/1/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is not suggestive to SZ/SZA.	Negative

Gene relationship with MDD

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Region: chr22:20241415..20283246 View in gBrowse