Gene Report

Basic Info
Approved Symbol NRXN3
Previous Symbol C14orf60
Symbol Alias KIAA0743
Approved Name neurexin 3
Previous Name chromosome 14 open reading frame 60
Location 14q31
Position chr14:78170373-79868290, 1
External Links HGNC: 8010
Entrez Gene: 9369
Ensembl: ENSG00000021645
UCSC: uc001xun.4
No. of Studies 2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kuo, P. H., 2014 SNP: rs2217887 Gene-based P-value (allelic model) =0.0071, P-value (additive model) =0.0095. NRXN3, which encodes receptors or ligands that regulate neuronal positioning, axon guidance, cell migration and adhesion (P= 0.0095) Positive Comment on Study
Noor A., 2014 Interestingly, in four unrelated BD cases, we identified CNVs involving members of the neurexin family of genes, including a loss and a gain - both exonic - at NRXN1 (also see de novo loss at NRXN1 in another BD subject, below), an intronic deletion in NRXN3 and a partial duplication (exonic) of NRXN2. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 19)

GO terms by PBA (count: 5)

GO terms by database search (count: 14)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 17)

Literature-origin SNPs (count: 1)

LD-proxies (count: 16)

Gene related CNVs (count: 1)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr14:78170373..79868290 View in gBrowse
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