Gene Report

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Basic Info

Approved Symbol	CTNND2
Symbol Alias	NPRAP, GT24
Approved Name	catenin (cadherin-associated protein), delta 2
Previous Name	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
Name Alias	neural plakophilin-related arm-repeat protein
Location	5p15.2
Position	chr5:10971840-11904043, -1
External Links	HGNC: 2516 Entrez Gene: 1501 Ensembl: ENSG00000169862 UCSC: uc003jfa.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Huang, J.,2010	SNP: rs194487	No significant association of this gene was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007275	multicellular organismal development	biological process	IEA	24
GO:0007155	cell adhesion	biological process	TAS[9223106]	42
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016337	single organismal cell-cell adhesion	biological process	IEA	10
GO:0001763	morphogenesis of a branching structure	biological process	IEA	2
GO:0007612	learning	biological process	IEA	18
GO:0005737	cytoplasm	cellular component	TAS[9342840]	322
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0043204	perikaryon	cellular component	IEA	17
GO:0007165	signal transduction	biological process	TAS[9223106]	136
GO:0048167	regulation of synaptic plasticity	biological process	IEA	9
GO:0005515	protein binding	molecular function	IPI[19706687]	563
GO:0005912	adherens junction	cellular component	IEA	4

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 12)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CTNND2	PDZD2	NO	in vitro;in vivo;yeast 2-hybrid	10896674
CTNND2	CDH1	NO	in vivo	9971746
CTNND2	MAGI2	YES	in vitro;in vivo	10080919
CTNND2	ERBB2IP	NO	in vitro;in vivo	11821434
CTNND2	LCK	NO	in vitro;in vivo	12835311
CTNND2	LRRC7	NO	in vitro;in vivo;yeast 2-hybrid	11729199
CTNND2	PSEN2	NO	in vivo	10037471
CTNND2	ABL1	NO	in vitro	11891774
CTNND2	PSEN1	NO	in vitro;in vivo;yeast 2-hybrid	9223106 , 10208590 , 10037471
CTNND2	CDH2	NO	in vivo	9971746
CTNND2	CTNNB1	NO	in vivo	9971746
CTNND2	SPHK1	NO	in vivo;yeast 2-hybrid	15193146

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs194487	chr5:11252155 - 11252155(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5pter-p15.1	chr5:0-18400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
20713499	No significant association of this gene was observed in SZ.	Negative

Gene relationship with MDD

Reference	Description	Category in MDD
20713499	No significant association was observed in MDD.	Negative

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Region: chr5:10971840..11904043 View in gBrowse