Gene Report

Basic Info
Approved Symbol CLOCK
Symbol Alias KIAA0334, KAT13D, bHLHe8
Approved Name clock circadian regulator
Previous Name clock (mouse) homolog, "clock homolog (mouse)"
Location 4q12
Position chr4:55427903-55547138, -1
External Links HGNC: 2082
Entrez Gene: 9575
Ensembl: ENSG00000134852
UCSC: uc003hba.2
No. of Studies 12 (Positive: 5; Negative: 7; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 12)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Byrne, E. M., 2014 P-value=0.29. It is notable that there are no SNPs in or near the TIMELESS gene that show evidence of association with risk to BPD, and similarly, the CLOCK gene harbors only one SNP that just reaches the nominal significance threshold (P=0.042), indicating that these genes are not strong candidates for influencing BPD risk in the population. Negative Comment on Study
Yosifova, A.,2009 SNP: rs1801260 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Mansour, H. A.,2009 Gene-based tests:X<sup>2</sup>=5.096, P-value = 0.142 in dominant model, X<sup>2</sup>=3.578, P-value = 0.434 in recessive model, X<sup>2</sup>=2.556, P-value = 0.524 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. Negative Comment on Study
Kripke, D. F.,2009 SNP: rs12504300, rs12648271, rs3736544, rs3805148, rs4864542, rs6850524 Significant association was observed in the BP group. Positive Comment on Study
Kishi, T.,2009(a) SNP: rs11133385, rs11931061, rs11939815, rs1801260, rs3736544, rs3749474
Haplotype: rs11939815 - rs11931061 - rs11133385 - rs3736544 - rs1801260 - rs3749474()
In conclusion, we suggest that CLOCK may not play a major role in the pathophysiology of schizophrenia, BP and MDD in the Japanese population. Negative Comment on Study
Mansour, H. A., 2006 No significant association was detected in any sample using any test. Negative Comment on Study
Dmitrzak-Weglarz, M. P., 2014 SNP: rs1801260, rs11932595, rs12648271
Haplotype: rs534654 - rs534654 - rs3805148(G-A-C), rs534654 - rs534654 - rs3805148(G-G-A), rs534654 - rs534654 - rs3805148(G-A-A), rs534654 - rs534654 - rs3805148(A-A-A)
We found significant association between two CLOCK SNPs (rs1801260 and rs11932595) and BPDII. Positive Comment on Study
Lee, K. Y.,2010 SNP: rs1801260 Despite the relatively small sample sizes, these results support a possible role of the CLOCK 3111T/C SNP in bipolar disorder. Positive Comment on Study
Soria, V.,2010 SNP: rs10462028, rs11133379, rs12504300, rs1801260, rs2070062, rs6850524 Significant associations of CLOCK gene were found in BPD patients. Positive Comment on Study
Kishi, T.,2011(c) SNP: rs1801260, rs3736544, rs3749474 We did not detect any associations between tagging SNPs in CLOCK and BP or MDD. Negative Comment on Study
Shi, J., 2008 (d) SNP: rs11735267, rs2412648, rs4340844, rs534654, rs6850524, rs7660668
Haplotype: rs534654 - rs2412648 - rs4340844 - rs11735267 - rs6850524 - rs7660668 (GAAACG), rs534654 - rs2412648 - rs4340844 - rs11735267 - rs6850524 - rs7660668 (GACAGC), rs534654 - rs2412648 - rs4340844 - rs11735267 - rs6850524 - rs7660668 (AAAGCC), rs2137947 - rs6850524 - rs1534891()
rs534654, TDT P = 0.0097; rs6850524, TDT P = 0.012; rs4340844, TDT P = 0.015. Three SNPs at the CLOCK gene region showed suggestive evidence for transmission disequilibrium. However, none of these associations reached gene-wide or experiment-wide significance after correction for multiple-testing. Positive Comment on Study
Nievergelt, C. M., 2006 Single SNP TDT analyses showed no evidence for association to BPAD. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 44)

GO terms by PBA (count: 5)

GO terms by database search (count: 39)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 125)

Literature-origin SNPs (count: 20)

LD-proxies (count: 105)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 3)

Overlap with SZ from candidate gene intersection analysis (count: 5)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 4)

Overlap with MDD from candidate gene intersection analysis (count: 3)

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Region: chr4:55427903..55547138 View in gBrowse
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