Gene Report

Approved Symbol	CLOCK
Symbol Alias	KIAA0334, KAT13D, bHLHe8
Approved Name	clock circadian regulator
Previous Name	clock (mouse) homolog, "clock homolog (mouse)"
Location	4q12
Position	chr4:55427903-55547138, -1
External Links	HGNC: 2082 Entrez Gene: 9575 Ensembl: ENSG00000134852 UCSC: uc003hba.2
No. of Studies	12 (Positive: 5; Negative: 7; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Byrne, E. M., 2014		P-value=0.29. It is notable that there are no SNPs in or near the TIMELESS gene that show evidence of association with risk to BPD, and similarly, the CLOCK gene harbors only one SNP that just reaches the nominal significance threshold (P=0.042), indicating that these genes are not strong candidates for influencing BPD risk in the population.	Negative	Comment on Study
Yosifova, A.,2009	SNP: rs1801260	No SNP of this gene had significant association with BD in our population.	Negative	Comment on Study
Mansour, H. A.,2009		Gene-based tests:X<sup>2</sup>=5.096, P-value = 0.142 in dominant model, X<sup>2</sup>=3.578, P-value = 0.434 in recessive model, X<sup>2</sup>=2.556, P-value = 0.524 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI.	Negative	Comment on Study
Kripke, D. F.,2009	SNP: rs12504300, rs12648271, rs3736544, rs3805148, rs4864542, rs6850524	Significant association was observed in the BP group.	Positive	Comment on Study
Kishi, T.,2009(a)	SNP: rs11133385, rs11931061, rs11939815, rs1801260, rs3736544, rs3749474 Haplotype: rs11939815 - rs11931061 - rs11133385 - rs3736544 - rs1801260 - rs3749474()	In conclusion, we suggest that CLOCK may not play a major role in the pathophysiology of schizophrenia, BP and MDD in the Japanese population.	Negative	Comment on Study
Mansour, H. A., 2006		No significant association was detected in any sample using any test.	Negative	Comment on Study
Dmitrzak-Weglarz, M. P., 2014	SNP: rs1801260, rs11932595, rs12648271 Haplotype: rs534654 - rs534654 - rs3805148(G-A-C), rs534654 - rs534654 - rs3805148(G-G-A), rs534654 - rs534654 - rs3805148(G-A-A), rs534654 - rs534654 - rs3805148(A-A-A)	We found significant association between two CLOCK SNPs (rs1801260 and rs11932595) and BPDII.	Positive	Comment on Study
Lee, K. Y.,2010	SNP: rs1801260	Despite the relatively small sample sizes, these results support a possible role of the CLOCK 3111T/C SNP in bipolar disorder.	Positive	Comment on Study
Soria, V.,2010	SNP: rs10462028, rs11133379, rs12504300, rs1801260, rs2070062, rs6850524	Significant associations of CLOCK gene were found in BPD patients.	Positive	Comment on Study
Kishi, T.,2011(c)	SNP: rs1801260, rs3736544, rs3749474	We did not detect any associations between tagging SNPs in CLOCK and BP or MDD.	Negative	Comment on Study
Shi, J., 2008 (d)	SNP: rs11735267, rs2412648, rs4340844, rs534654, rs6850524, rs7660668 Haplotype: rs534654 - rs2412648 - rs4340844 - rs11735267 - rs6850524 - rs7660668 (GAAACG), rs534654 - rs2412648 - rs4340844 - rs11735267 - rs6850524 - rs7660668 (GACAGC), rs534654 - rs2412648 - rs4340844 - rs11735267 - rs6850524 - rs7660668 (AAAGCC), rs2137947 - rs6850524 - rs1534891()	rs534654, TDT P = 0.0097; rs6850524, TDT P = 0.012; rs4340844, TDT P = 0.015. Three SNPs at the CLOCK gene region showed suggestive evidence for transmission disequilibrium. However, none of these associations reached gene-wide or experiment-wide significance after correction for multiple-testing.	Positive	Comment on Study
Nievergelt, C. M., 2006		Single SNP TDT analyses showed no evidence for association to BPAD.	Negative	Comment on Study

Region: chr4:55427903..55547138 View in gBrowse