Gene Report

Basic Info
Approved Symbol TACR1
Previous Symbol TAC1R
Symbol Alias SPR, NK1R, NKIR
Approved Name tachykinin receptor 1
Location 2p13.1-p12
Position chr2:75046463-75199700, -1
External Links HGNC: 11526
Entrez Gene: 6869
Ensembl: ENSG00000115353
UCSC: uc002sng.2
No. of Studies 3 (Positive: 3; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Perlis, 2008 SNP: rs1106855, rs3755456, rs3771809, rs4439987, rs6546952 permuted P< .005 in gene-based association tests. No genes specifically chosen to probe the action of lithium were associated with bipolar disorder. However, gene-based analysis of sialyltransferase 4A (SIAT4A), tachykinin receptor 1 (TACR1), and -aminobutyric acidA 2 receptor subunit (GABRB2) yielded evidence of association. Positive Comment on Study
Gratacos, M.,2009 SNP: rs11684394 Nominal associations with bipolar disorder was observed. Positive Comment on Study
Sharp S.I., 2014 SNP: rs17011370, rs59099335, rs34374747, rs1477157, rs1477156, rs13387833, rs2111375, rs13384011, rs2193405, rs10210648, rs200655774, rs6715729, rs2024512, rs3771856, rs3771833, rs3771829, rs78052302, rs201914096, rs1106854, rs881, rs17010664, rs12713828, rs74376589, rs183232680, rs191039988, rs79127835, rs72918532, rs115249523, rs189985009, rs146950668, rs77446510, rs182005577, rs187211761, rs7582109, rs115963180, rs73935535, rs189288944, rs141271615, rs72918549, rs139788317, rs140181726, rs114427038, rs181219209, rs73935540, rs184935933, rs72918570, rs76517971, rs7588326, rs191875370, rs193032314, rs147834749, rs76775346, rs185595660, rs181192058, rs114063455, rs3771827, rs741420, rs143757550, rs7581675, rs144018010, rs192905448, rs185152963, rs58913381, rs188368822, rs113702328, rs182967369, rs147031506, rs181659924, rs145228980, rs147054223, rs2422148, rs139759288, rs12469836, rs187148246, rs72920676, rs151313513, rs186366225, rs190748962, rs141945058, rs186012981, rs112389239, rs114752002, rs6731496, rs112514340
Other variant: TACR1_ss825678898, TACR1_Chr2:75280719:D, TACR1_Chr2:75327565:D, TACR1_Chr2:75339547:D, TACR1_Chr2:75359623:D
Polymorphisms in TACR1 significantly increase susceptibility to BPAD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 51)

GO terms by PBA (count: 3)

GO terms by database search (count: 48)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Related other genetic factors
Gene related SNPs (count: 145)

Literature-origin SNPs (count: 91)

LD-proxies (count: 54)

Gene related CNVs (count: 0)

Gene related other variants (count: 5)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:75046463..75199700 View in gBrowse
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