Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	FZD3
Approved Name	frizzled class receptor 3
Previous Name	frizzled (Drosophila) homolog 3, "frizzled homolog 3 (Drosophila)", "frizzled 3, seven transmembrane spanning receptor", "frizzled family receptor 3"
Location	8p21
Position	chr8:28494205-28574268, 1
External Links	HGNC: 4041 Entrez Gene: 7976 Ensembl: ENSG00000104290 UCSC: uc010lvb.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Hashimoto, R.,2005(b)	SNP: rs2241802, rs2323019, rs352203, rs960914 Haplotype: rs960914 - rs2241802 - rs2323019 - rs352203()	In conclusion, we obtained no evidence for an association between the FZD3 gene and schizophrenia or mood disorders, suggesting that this gene has no major role in conferring susceptibility to major psychoses in our sample.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 31)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030165	PDZ domain binding	molecular function	IPI[18256285]	16
GO:0005886	plasma membrane	cellular component	IDA[19038973]; TAS	360
GO:0016021	integral component of membrane	cellular component	IBA	219

GO terms by database search (count: 28)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0042472	inner ear morphogenesis	biological process	IEA	8
GO:0005737	cytoplasm	cellular component	IDA[19038973]	322
GO:0001942	hair follicle development	biological process	IEA	4
GO:0004930	G-protein coupled receptor activity	molecular function	IBA	26
GO:0033278	cell proliferation in midbrain	biological process	IEA	1
GO:0042813	Wnt-activated receptor activity	molecular function	IBA; IC[19038973]	2
GO:0061549	sympathetic ganglion development	biological process	ISS	1
GO:0060070	canonical Wnt signaling pathway	biological process	IDA[20802536]	9
GO:0009986	cell surface	cellular component	IEA	40
GO:0071679	commissural neuron axon guidance	biological process	IEA	1
GO:0001843	neural tube closure	biological process	IEA	8
GO:0036342	post-anal tail morphogenesis	biological process	IEA	2
GO:0001764	neuron migration	biological process	IEA	18
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IEA	64
GO:0043025	neuronal cell body	cellular component	IEA	50
GO:0005515	protein binding	molecular function	IPI[19277043]	563
GO:0030425	dendrite	cellular component	IEA	65
GO:0045976	negative regulation of mitotic cell cycle, embryonic	biological process	ISS	1
GO:0035567	non-canonical Wnt signaling pathway	biological process	IBA	2
GO:0030424	axon	cellular component	IEA	39
GO:0048786	presynaptic active zone	cellular component	IEA	5
GO:0002052	positive regulation of neuroblast proliferation	biological process	ISS	4
GO:0030182	neuron differentiation	biological process	ISS	5
GO:0001736	establishment of planar polarity	biological process	IEA	3
GO:0016328	lateral plasma membrane	cellular component	IEA	7
GO:0017147	Wnt-protein binding	molecular function	IPI[19038973]	5
GO:0016324	apical plasma membrane	cellular component	IEA	24
GO:1900118	negative regulation of execution phase of apoptosis	biological process	ISS	2

Gene related KEGG pathways (count: 4)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa05217	Basal cell carcinoma	8

KEGG pathways by database search (count: 3)

ID	Name	No. of Genes in BDgene
hsa05210	Colorectal cancer	14
hsa04310	Wnt signaling pathway	20
hsa04916	Melanogenesis	16

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
FZD3	GIPC1	NO	in vivo	12011974
FZD3	GIPC2	YES	in vivo	12011974
FZD3	GIPC3	NO	in vivo	12011974

Related other genetic factors

Gene related SNPs (count: 43)

Literature-origin SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs960914	chr8:28503460 - 28503460(1)	downstream_gene_variant; intron_variant	1(0/1/0)
rs352203	chr8:28537184 - 28537184(1)	intron_variant	1(0/1/0)
rs2241802	chr8:28527195 - 28527195(1)	synonymous_variant; upstream_gene_variant	1(0/1/0)
rs2323019	chr8:28533453 - 28533453(1)	downstream_gene_variant; intron_variant	1(0/1/0)

LD-proxies (count: 39)

rs_ID	Location	Functional Annotation
rs7001034	chr8:28505861 - 28505861(1)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs7842884	chr8:28504942 - 28504942(1)	downstream_gene_variant; intron_variant
rs6984655	chr8:28511580 - 28511580(1)	intron_variant
rs7844545	chr8:28508024 - 28508024(1)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs13280925	chr8:28543773 - 28543773(1)	intron_variant
rs11783087	chr8:28546510 - 28546510(1)	intron_variant
rs12677252	chr8:28550224 - 28550224(1)	intron_variant
rs352227	chr8:28551179 - 28551179(1)	intron_variant
rs2874941	chr8:28515831 - 28515831(1)	intron_variant
rs352210	chr8:28524903 - 28524903(1)	intron_variant
rs6987561	chr8:28524967 - 28524967(1)	intron_variant
rs164667	chr8:28542114 - 28542114(1)	intron_variant
rs352222	chr8:28564264 - 28564264(1)	3_prime_UTR_variant; downstream_gene_variant
rs352220	chr8:28567992 - 28567992(1)	3_prime_UTR_variant; downstream_gene_variant
rs352217	chr8:28568746 - 28568746(1)	3_prime_UTR_variant; downstream_gene_variant
rs4415271	chr8:28568902 - 28568902(1)	3_prime_UTR_variant; downstream_gene_variant
rs352226	chr8:28552522 - 28552522(1)	intron_variant
rs10092491	chr8:28553555 - 28553555(1)	intron_variant
rs352436	chr8:28555067 - 28555067(1)	intron_variant
rs893306	chr8:28556431 - 28556431(1)	intron_variant
rs11775139	chr8:28498190 - 28498190(1)	intron_variant
rs6997072	chr8:28502094 - 28502094(1)	downstream_gene_variant; intron_variant
rs7833751	chr8:28505275 - 28505275(1)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs2043182	chr8:28509670 - 28509670(1)	intron_variant; upstream_gene_variant
rs13271137	chr8:28578670 - 28578670(1)	downstream_gene_variant
rs6984625	chr8:28511526 - 28511526(1)	intron_variant
rs352214	chr8:28577124 - 28577124(1)	downstream_gene_variant
rs4732861	chr8:28531489 - 28531489(1)	downstream_gene_variant; intron_variant
rs10089889	chr8:28575359 - 28575359(1)	downstream_gene_variant
rs2323021	chr8:28554398 - 28554398(1)	intron_variant
rs11779401	chr8:28578151 - 28578151(1)	downstream_gene_variant
rs13275556	chr8:28554905 - 28554905(1)	intron_variant
rs2323022	chr8:28554443 - 28554443(1)	intron_variant
rs13260884	chr8:28558312 - 28558312(1)	intron_variant; upstream_gene_variant
rs17517918	chr8:28557335 - 28557335(1)	intron_variant
rs4732863	chr8:28564971 - 28564971(1)	3_prime_UTR_variant; downstream_gene_variant
rs6980605	chr8:28559034 - 28559034(1)	intron_variant; upstream_gene_variant
rs8042	chr8:28573683 - 28573683(1)	3_prime_UTR_variant
rs4732642	chr8:28569918 - 28569918(1)	3_prime_UTR_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8p21	chr8:19200000-29000000	2 (0/1/1)
Chr 8	chr8:0-145138636	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
15657645	In conclusion, we obtained no evidence for an association between the FZD3 gene and schizophrenia or mood disorders, suggesting that this gene has no major role in conferring susceptibility to major psychoses in our sample.	Negative

Overlap with SZ from candidate gene intersection analysis (count: 9)

Reference	ID in SZGene	Result Category
14642436	306	Positive
15657645	306	Negative
17982906	306	Negative
15274031	306	Positive
17553464	306	Negative
15364045	306	Negative
16707163	306	Negative
14643098	306	Positive
15288446	306	Negative

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
15657645	In conclusion, we obtained no evidence for an association between the FZD3 gene and schizophrenia or mood disorders, suggesting that this gene has no major role in conferring susceptibility to major psychoses in our sample.	Negative

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr8:28494205..28574268 View in gBrowse