Gene Report

Basic Info
Approved Symbol FZD3
Approved Name frizzled class receptor 3
Previous Name frizzled (Drosophila) homolog 3, "frizzled homolog 3 (Drosophila)", "frizzled 3, seven transmembrane spanning receptor", "frizzled family receptor 3"
Location 8p21
Position chr8:28494205-28574268, 1
External Links HGNC: 4041
Entrez Gene: 7976
Ensembl: ENSG00000104290
UCSC: uc010lvb.3
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Hashimoto, R.,2005(b) SNP: rs2241802, rs2323019, rs352203, rs960914
Haplotype: rs960914 - rs2241802 - rs2323019 - rs352203()
In conclusion, we obtained no evidence for an association between the FZD3 gene and schizophrenia or mood disorders, suggesting that this gene has no major role in conferring susceptibility to major psychoses in our sample. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 31)

GO terms by PBA (count: 3)

GO terms by database search (count: 28)

Gene related KEGG pathways (count: 4)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 3)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 43)

Literature-origin SNPs (count: 4)

LD-proxies (count: 39)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 9)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr8:28494205..28574268 View in gBrowse
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