Gene Report

Basic Info
Approved Symbol TLE4
Symbol Alias E(spI), ESG, GRG4
Approved Name transducin-like enhancer of split 4
Previous Name transducin-like enhancer of split 4, homolog of Drosophila E(sp1), "transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)"
Location 9q21.32
Position chr9:79571773-79726882, 1
External Links HGNC: 11840
Entrez Gene: 7091
Ensembl: ENSG00000106829
UCSC: uc004alc.4
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Moskvina, V.,2009 In BP:Smallest P-value per gene=0.00011, Product of P truncation <=0.01=0.02999, Product of P truncation <=0.001=0.00392. It showed evidence for association with BD. Positive Comment on Study
Cichon, S.,2011 SNP: rs2209263 No positive signal in this gene was observed for BD. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 13)

GO terms by PBA (count: 2)

GO terms by database search (count: 11)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Related other genetic factors
Gene related SNPs (count: 2)

Literature-origin SNPs (count: 2)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 6)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

View in gBrowse

Region: chr9:79571773..79726882 View in gBrowse
View in gBrowse