BDgene

Gene Report

Basic Info
Approved Symbol HTR5A
Symbol Alias 5-HT5A
Approved Name 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
Previous Name 5-hydroxytryptamine (serotonin) receptor 5A
Location 7q36.1
Position chr7:155070324-155085749, 1
External Links HGNC: 5300
Entrez Gene: 3361
Ensembl: ENSG00000157219
UCSC: uc003wlu.2
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Yosifova, A.,2009 SNP: rs1800883
Haplotype: rs1800883 - rs2581841 - rs10254608(C-C-C), rs1800883 - rs2581841 - rs10254608(G-T-A)
Significant association of SNP in this gene with BD in our population was observed. Positive Comment on Study
Arias, B., 2001 Other variant: HTR5A_12A/T, HTR5A_19G/C In summary, we did not find evidence for association between variability of the 5-HT5A human receptor gene and affective disorders. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 13)

GO terms by PBA (count: 2)

GO terms by database search (count: 11)


Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 1)


Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

LD-proxies (count: 0)


Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 3)


Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 1)


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Region: chr7:155070324..155085749 View in gBrowse
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