Gene Report

Approved Symbol	PLA2G6
Symbol Alias	iPLA2, PNPLA9, PARK14, iPLA2beta, NBIA2
Approved Name	phospholipase A2, group VI (cytosolic, calcium-independent)
Name Alias	neurodegeneration with brain iron accumulation 2
Location	22q13.1
Position	chr22:38111495-38205690, -1
External Links	HGNC: 9039 Entrez Gene: 8398 Ensembl: ENSG00000184381 UCSC: uc003aux.1
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, C.,2012	SNP: rs4375, rs3788533 Haplotype: rs4375 - rs3788533(T-C), rs4375 - rs3788533(C-G)	Association with BD as a whole was observed in the family study (significant over transmissions of rs3788533-allele C, P=0.015, PBonferroni=0.03, TDTPHASE). A significant association of iPLA2beta variants with BD-I and a trend gene-gene interaction between iPLA2beta and TRPM2 provides additional support for the notion that genetic variation in these two functionally implicated candidates contributes toward the risk and pathophysiology of this illness.	Positive	Comment on Study
Meira-Lima, I.,2003(a)	Other variant: iPLA2_C/T	Our results failed to demonstrate that the studied PLA2 polymorphisms were associated with an increased risk for BPAD in our sample.	Negative	Comment on Study

Region: chr22:38111495..38205690 View in gBrowse