Gene Report

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Basic Info

Approved Symbol	COX10
Approved Name	COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
Previous Name	COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast), "cytochrome c oxidase assembly homolog 10 (yeast)"
Name Alias	protoheme IX farnesyltransferase, mitochondrial, "heme O synthase"
Location	17p12
Position	chr17:14069496-14208677, 1
External Links	HGNC: 2260 Entrez Gene: 1352 Ensembl: ENSG00000006695 UCSC: uc002gof.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0025. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0000266	mitochondrial fission	biological process	IEA	4
GO:0005743	mitochondrial inner membrane	cellular component	TAS	12
GO:0006778	porphyrin-containing compound metabolic process	biological process	TAS	1
GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	biological process	IC[12928484]	1
GO:0045333	cellular respiration	biological process	IGI[10767350]	1
GO:0048034	heme O biosynthetic process	biological process	IEA	1
GO:0006783	heme biosynthetic process	biological process	TAS	2
GO:0004129	cytochrome-c oxidase activity	molecular function	IMP[12928484]	2
GO:0004311	farnesyltranstransferase activity	molecular function	TAS[8078902]	1
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:1902600	hydrogen ion transmembrane transport	biological process	IMP[12928484]	4
GO:0008535	respiratory chain complex IV assembly	biological process	IMP[14607829]	1
GO:0009060	aerobic respiration	biological process	IEA	2
GO:0070069	cytochrome complex	cellular component	IMP[12928484]	1
GO:0006784	heme a biosynthetic process	biological process	IMP[12928484]	1
GO:0005739	mitochondrion	cellular component	IC[14607829]	75
GO:0008495	protoheme IX farnesyltransferase activity	molecular function	IEA	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00860	Porphyrin and chlorophyll metabolism	1

ID	Name	No. of Genes in BDgene	Brief Description
hsa00190	Oxidative phosphorylation	7

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Zhang[2009]_282	chr17:14034987-15425596 (Affymetrix SNP 6.0 array reference genome)	1390609		Singleton deletions

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
17p13.1-17p12	chr17:6500000-16100000	1 (0/1/0)
17p12-q21.33	chr17:10800000-52100000	1 (0/1/0)
17p12	chr17:10800000-16100000	2 (0/1/1)
Chr 17	chr17:0-83257441	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr17:14069496..14208677 View in gBrowse