Gene Report

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Basic Info

Approved Symbol	SNX4
Symbol Alias	ATG24B
Approved Name	sorting nexin 4
Location	3q21.2
Position	chr3:125446644-125520197, -1
External Links	HGNC: 11175 Entrez Gene: 8723 Ensembl: ENSG00000114520 UCSC: uc003eib.4
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Malhotra, D.,2011		A de novo CNV related with this gene is discovered and validated in our study	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005158	insulin receptor binding	molecular function	IDA[9819414]	5
GO:0005886	plasma membrane	cellular component	IDA[18253931]	360
GO:0016020	membrane	cellular component	IDA[9819414]	137

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0035091	phosphatidylinositol binding	molecular function	IMP[17994011]	5
GO:0031901	early endosome membrane	cellular component	IDA[17994011]	8
GO:1903595	positive regulation of histamine secretion by mast cell	biological process	IMP[18253931]	2
GO:0031201	SNARE complex	cellular component	IDA[18253931]	8
GO:0005515	protein binding	molecular function	IPI[11278302]	563
GO:0015031	protein transport	biological process	IMP[17994011]	21
GO:0043234	protein complex	cellular component	IDA[9819414]	27
GO:0019898	extrinsic component of membrane	cellular component	IBA	8
GO:0032456	endocytic recycling	biological process	IMP[17994011]	2
GO:0005154	epidermal growth factor receptor binding	molecular function	IDA[9819414]	3
GO:1990459	transferrin receptor binding	molecular function	IDA[9819414]	1
GO:0005737	cytoplasm	cellular component	IDA[11279102]	322
GO:1990460	leptin receptor binding	molecular function	IDA[9819414]	1
GO:0016050	vesicle organization	biological process	IBA	1
GO:0005868	cytoplasmic dynein complex	cellular component	IDA[17994011]	3

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SNX4	PDGFRA	NO	in vivo	9819414
SNX4	AGK	NO	yeast 2-hybrid	16169070
SNX4	SNX2	NO	in vitro;in vivo	9819414
SNX4	BIN1	NO	in vivo;yeast 2-hybrid	12668730
SNX4	INSR	NO	in vivo	9819414
SNX4	SNX6	NO	in vitro;in vivo	11279102
SNX4	PDGFRB	YES	in vitro	9819414

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Malhotra[2011]_1	chr3:126663504-126720022 (NCBI Build 36 (hg18))	56519	3q21.2	deletion	De Novo

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
3q21	chr3:122200000-129500000	1 (0/1/0)
3q21.1-q21.2	chr3:122200000-126100000	1 (0/0/1)
Chr 3	chr3:0-198295559	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:125446644..125520197 View in gBrowse