Gene Report

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Basic Info

Approved Symbol	TNR
Approved Name	tenascin R
Name Alias	restrictin, "janusin"
Location	1q24
Position	chr1:175315194-175743770, -1
External Links	HGNC: 11953 Entrez Gene: 7143 Ensembl: ENSG00000116147 UCSC: uc009wwu.1
No. of Studies	2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Green, E. K.,2012	SNP: rs875326	BD ImmunoChip:P-value = 0.378,OR = 0.945;ImmunoChip, PGC-BD combined data:P-balue = 0.00105,OR = 1.078 No significant association was observed.	Negative	Comment on Study
Sklar, P.,2011	SNP: rs875326	No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007411	axon guidance	biological process	NAS[8940128]	60
GO:0007155	cell adhesion	biological process	NAS[8940128]	42
GO:0005634	nucleus	cellular component	IDA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0060291	long-term synaptic potentiation	biological process	IEA	14
GO:0007158	neuron cell-cell adhesion	biological process	IEA	6
GO:0050805	negative regulation of synaptic transmission	biological process	IEA	2
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0030198	extracellular matrix organization	biological process	TAS	26
GO:0008306	associative learning	biological process	IEA	8
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0022408	negative regulation of cell-cell adhesion	biological process	IEA	1
GO:0051968	positive regulation of synaptic transmission, glutamatergic	biological process	IEA	8
GO:0050808	synapse organization	biological process	IEA	3
GO:0005578	proteinaceous extracellular matrix	cellular component	IEA	19
GO:0005576	extracellular region	cellular component	TAS	97
GO:0045121	membrane raft	cellular component	IEA	22
GO:0022029	telencephalon cell migration	biological process	IEA	2
GO:0072534	perineuronal net	cellular component	IEA	2
GO:0048692	negative regulation of axon extension involved in regeneration	biological process	IEA	1
GO:0050885	neuromuscular process controlling balance	biological process	IEA	6
GO:0035641	locomotory exploration behavior	biological process	IEA	4
GO:0009986	cell surface	cellular component	IEA	40
GO:0051971	positive regulation of transmission of nerve impulse	biological process	IEA	3

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04510	Focal adhesion	22
hsa04512	ECM-receptor interaction	9

ID	Name	No. of Genes in BDgene	Brief Description
hsa01430	Cell Communication	11

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TNR	NFASC	NO	in vitro	9722619
TNR	CNTN1	NO	in vivo	9081628 , 9335257
TNR	BCAN	NO	in vitro	9294172
TNR	VCAN	NO	in vivo	9294172
TNR	SIGLEC1	NO	in vitro	10406848

Related other genetic factors

Gene related SNPs (count: 7)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs875326	chr1:175320263 - 175320263(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; non_coding_transcript_variant	2(0/2/0)

rs_ID	Location	Functional Annotation
rs7513605	chr1:175320200 - 175320200(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs10489323	chr1:175321430 - 175321430(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs11802001	chr1:175321719 - 175321719(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs7551235	chr1:175325139 - 175325139(1)	intron_variant; non_coding_transcript_variant
rs726030	chr1:175327093 - 175327093(1)	intron_variant; non_coding_transcript_variant
rs9283389	chr1:175340145 - 175340145(1)	downstream_gene_variant; intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p32.1-q31.1	chr1:58500000-190800000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)
1q24.2-q25.1	chr1:167200000-176100000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:175315194..175743770 View in gBrowse