Gene Report

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Basic Info

Approved Symbol	TNR
Approved Name	tenascin R
Name Alias	restrictin, "janusin"
Location	1q24
Position	chr1:175315194-175743770, -1
External Links	HGNC: 11953 Entrez Gene: 7143 Ensembl: ENSG00000116147 UCSC: uc009wwu.1
No. of Studies	2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Green, E. K.,2012	SNP: rs875326	BD ImmunoChip:P-value = 0.378,OR = 0.945;ImmunoChip, PGC-BD combined data:P-balue = 0.00105,OR = 1.078 No significant association was observed.	Negative	Comment on Study
Sklar, P.,2011	SNP: rs875326	No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007411	axon guidance	biological process	NAS[8940128]	60
GO:0007155	cell adhesion	biological process	NAS[8940128]	42
GO:0005634	nucleus	cellular component	IDA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0060291	long-term synaptic potentiation	biological process	IEA	14
GO:0007158	neuron cell-cell adhesion	biological process	IEA	6
GO:0050805	negative regulation of synaptic transmission	biological process	IEA	2
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0030198	extracellular matrix organization	biological process	TAS	26
GO:0008306	associative learning	biological process	IEA	8
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0022408	negative regulation of cell-cell adhesion	biological process	IEA	1
GO:0051968	positive regulation of synaptic transmission, glutamatergic	biological process	IEA	8
GO:0050808	synapse organization	biological process	IEA	3
GO:0005578	proteinaceous extracellular matrix	cellular component	IEA	19
GO:0005576	extracellular region	cellular component	TAS	97
GO:0045121	membrane raft	cellular component	IEA	22
GO:0022029	telencephalon cell migration	biological process	IEA	2
GO:0072534	perineuronal net	cellular component	IEA	2
GO:0048692	negative regulation of axon extension involved in regeneration	biological process	IEA	1
GO:0050885	neuromuscular process controlling balance	biological process	IEA	6
GO:0035641	locomotory exploration behavior	biological process	IEA	4
GO:0009986	cell surface	cellular component	IEA	40
GO:0051971	positive regulation of transmission of nerve impulse	biological process	IEA	3

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04510	Focal adhesion	22
hsa04512	ECM-receptor interaction	9

ID	Name	No. of Genes in BDgene	Brief Description
hsa01430	Cell Communication	11

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TNR	CNTN1	NO	in vivo	9081628 , 9335257
TNR	NFASC	NO	in vitro	9722619
TNR	BCAN	NO	in vitro	9294172
TNR	SIGLEC1	NO	in vitro	10406848
TNR	VCAN	NO	in vivo	9294172

Related other genetic factors

Gene related SNPs (count: 7)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs875326	chr1:175320263 - 175320263(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; non_coding_transcript_variant	2(0/2/0)

rs_ID	Location	Functional Annotation
rs7513605	chr1:175320200 - 175320200(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs10489323	chr1:175321430 - 175321430(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs11802001	chr1:175321719 - 175321719(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs7551235	chr1:175325139 - 175325139(1)	intron_variant; non_coding_transcript_variant
rs726030	chr1:175327093 - 175327093(1)	intron_variant; non_coding_transcript_variant
rs9283389	chr1:175340145 - 175340145(1)	downstream_gene_variant; intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p32.1-q31.1	chr1:58500000-190800000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)
1q24.2-q25.1	chr1:167200000-176100000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:175315194..175743770 View in gBrowse