Gene Report

Basic Info
Approved Symbol S100B
Symbol Alias S100beta
Approved Name S100 calcium binding protein B
Previous Name S100 calcium binding protein, beta (neural)
Location 21q22.3
Position chr21:46598962-46605208, -1
External Links HGNC: 10500
Entrez Gene: 6285
Ensembl: ENSG00000160307
UCSC: uc002zju.1
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Yosifova, A.,2009 SNP: rs2839350, rs3788266 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Roche, S., 2007 SNP: rs2839350, rs2839351, rs2839355, rs2839359, rs2839363, rs3788266, rs3804040, rs881827, rs9722
Haplotype: rs2839350 - rs2839351(A-C), rs2839351 - rs9722(C-C), rs2839355 - rs2839359(T-T), rs2839359 - rs2839363(T-A), rs2839363 - rs3788266(G-A(BPI)/G-G(BPI&psychosis)), rs3804040 - rs2839350(C-A), rs881827 - rs2839355(C-T(BPI)/T-C(BPI&psychosis)), rs9722 - rs881827(T-C(BPI)/C-C(BPI&psychosis))
The data suggest that variants within S100B predispose to a psychotic subtype of BPAD Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 34)

GO terms by PBA (count: 4)

GO terms by database search (count: 30)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 19)

Related other genetic factors
Gene related SNPs (count: 19)

Literature-origin SNPs (count: 9)

LD-proxies (count: 10)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 3)

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Region: chr21:46598962..46605208 View in gBrowse
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