Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	NEK7
Approved Name	NIMA-related kinase 7
Previous Name	NIMA (never in mitosis gene a)-related kinase 7
Location	1q31.3
Position	chr1:198156963-198322420, 1
External Links	HGNC: 13386 Entrez Gene: 140609 Ensembl: ENSG00000151414 UCSC: uc001gun.4
No. of Studies	2 (Positive: 0; Negative: 1; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs10922418, rs12025074, rs4412625, rs6428445	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study
Smith, E. N.,2011	SNP: rs1927252	Suggestive association of this gene was found.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004674	protein serine/threonine kinase activity	molecular function	IBA; ISS	27

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0000922	spindle pole	cellular component	IEA	6
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0005815	microtubule organizing center	cellular component	IEA	10
GO:0009966	regulation of signal transduction	biological process	IEA	4
GO:0007346	regulation of mitotic cell cycle	biological process	TAS[17727698]	3
GO:0006468	protein phosphorylation	biological process	IDA[12840024]	42
GO:0005874	microtubule	cellular component	IEA	24
GO:0005524	ATP binding	molecular function	IEA	118
GO:0000910	cytokinesis	biological process	TAS[17727698]	5
GO:0051225	spindle assembly	biological process	TAS[17727698]	3
GO:0046872	metal ion binding	molecular function	IEA	115

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NEK7	NEK9	NO	in vitro;in vivo	12840024

Related other genetic factors

Gene related SNPs (count: 31)

Literature-origin SNPs (count: 5)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1927252	chr1:198264777 - 198264777(1)	downstream_gene_variant; intron_variant	1(0/0/1)
rs12025074	chr1:198205733 - 198205733(1)	intron_variant; upstream_gene_variant	1(0/1/0)
rs10922418	chrCHR_HSCHR1_3_CTG31:198415856 - 198415856(1)		1(0/1/0)
rs6428445	chr1:198243506 - 198243506(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs4412625	chrCHR_HSCHR1_3_CTG31:198392289 - 198392289(1)		1(0/1/0)

LD-proxies (count: 26)

rs_ID	Location	Functional Annotation
rs6661361	chr1:198324895 - 198324895(1)	downstream_gene_variant
rs7529192	chr1:198317710 - 198317710(1)	intron_variant; non_coding_transcript_variant
rs10801664	chr1:198315778 - 198315778(1)	intron_variant; non_coding_transcript_variant
rs11588882	chr1:198322577 - 198322577(1)	downstream_gene_variant
rs6679100	chr1:198319579 - 198319579(1)	3_prime_UTR_variant; downstream_gene_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs4403652	chr1:198231995 - 198231995(1)	intron_variant; non_coding_transcript_variant
rs4915269	chr1:198203273 - 198203273(1)	intron_variant; upstream_gene_variant
rs10157311	chr1:198272409 - 198272409(1)	intron_variant
rs12123239	chr1:198270681 - 198270681(1)	intron_variant
rs12059603	chr1:198260106 - 198260106(1)	downstream_gene_variant; intron_variant
rs1475424	chr1:198254283 - 198254283(1)	downstream_gene_variant; intron_variant
rs6428449	chr1:198289796 - 198289796(1)	intron_variant; non_coding_transcript_variant
rs12561959	chr1:198324444 - 198324444(1)	downstream_gene_variant
rs12093069	chr1:198307669 - 198307669(1)	intron_variant; non_coding_transcript_variant
rs12083719	chr1:198305583 - 198305583(1)	intron_variant; non_coding_transcript_variant
rs7549003	chr1:198238483 - 198238483(1)	intron_variant; non_coding_transcript_variant
rs12036839	chr1:198231932 - 198231932(1)	intron_variant; non_coding_transcript_variant
rs1967824	chr1:198231420 - 198231420(1)	intron_variant; non_coding_transcript_variant
rs2884687	chr1:198226169 - 198226169(1)	intron_variant; non_coding_transcript_variant
rs12075431	chr1:198294611 - 198294611(1)	intron_variant; non_coding_transcript_variant
rs7541970	chr1:198256929 - 198256929(1)	downstream_gene_variant; intron_variant
rs6428447	chr1:198247567 - 198247567(1)	downstream_gene_variant; intron_variant
rs10494763	chr1:198238887 - 198238887(1)	intron_variant; non_coding_transcript_variant
rs12058769	chr1:198207593 - 198207593(1)	intron_variant; upstream_gene_variant
rs6691189	chr1:198219619 - 198219619(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs6672260	chr1:198326548 - 198326548(1)	downstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1q31.3	chr1:193800000-198700000	1 (1/0/0)
1q31-q32	chr1:185800000-214400000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:198156963..198322420 View in gBrowse