Gene Report

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Basic Info

Approved Symbol	FAM84B
Symbol Alias	BCMP101, NSE2
Approved Name	family with sequence similarity 84, member B
Name Alias	breast cancer membrane-associated protein 101, "neurological/sensory 2"
Location	8q24.13
Position	chr8:126552442-126558393, -1
External Links	HGNC: 24166 Entrez Gene: 157638 Ensembl: ENSG00000168672 UCSC: uc003yrz.2
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs7814955, rs974450	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study
Zandi, P. P., 2008 (b)		None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our threshold for study-wide significance (P<3.00E-05). However, there was consistent evidence at our threshold for the suggestive level (P<7.00E-04) from both the single locus and multi-locus tests of associations with SNPs in the genes ADCY8, ST3GAL1, and NSE2.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IDA[12477722]	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005515	protein binding	molecular function	IPI[12477722]	563
GO:0005737	cytoplasm	cellular component	IDA[12477722]	322

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
FAM84B	CTNNA1	NO	yeast 2-hybrid	12477722

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs974450	chr8:126695579 - 126695579(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs7814955	chr8:126409845 - 126409845(1)		1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8q24.13-q24.3	chr8:121500000-145138636	1 (1/0/0)
8q24.21-qter	chr8:126300000-145138636	1 (0/1/0)
Chr 8	chr8:0-145138636	3 (0/3/0)
8q24	chr8:116700000-145138636	7 (2/2/3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr8:126552442..126558393 View in gBrowse