Gene Report

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Basic Info

Approved Symbol	SERINC1
Previous Symbol	TDE2
Symbol Alias	TMS-2, TDE1L, KIAA1253
Approved Name	serine incorporator 1
Previous Name	tumor differentially expressed 2
Location	6q22.32
Position	chr6:122443354-122471822, -1
External Links	HGNC: 13464 Entrez Gene: 57515 Ensembl: ENSG00000111897 UCSC: uc003pyy.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fan, J., 2010		For gene-based test, P-value = 0.017 in STEP1. nominally significant in STEP1 sample, but not survive Bonferroni correction test.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005886	plasma membrane	cellular component	ISS	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0051347	positive regulation of transferase activity	biological process	ISS	1
GO:0006658	phosphatidylserine metabolic process	biological process	ISS	1
GO:0005515	protein binding	molecular function	IPI[20195357]	563
GO:0015194	L-serine transmembrane transporter activity	molecular function	ISS	2
GO:0008654	phospholipid biosynthetic process	biological process	IEA	2
GO:0015825	L-serine transport	biological process	ISS	2
GO:0006665	sphingolipid metabolic process	biological process	ISS	6
GO:0005789	endoplasmic reticulum membrane	cellular component	ISS	52
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q22.1-6q22.33	chr6:114200000-130000000	1 (0/1/0)
6q21-22	chr6:105000000-130000000	1 (0/0/1)
6q22	chr6:114200000-130000000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr6:122443354..122471822 View in gBrowse