Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	PTPRO
Symbol Alias	PTPU2, GLEPP1, PTP-U2, PTP-oc, NPHS6
Approved Name	protein tyrosine phosphatase, receptor type, O
Name Alias	osteoclastic transmembrane protein-tyrosine phosphatase
Location	12p13-p12
Position	chr12:15322397-15597399, 1
External Links	HGNC: 9678 Entrez Gene: 5800 Ensembl: ENSG00000151490 UCSC: uc001rcv.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs11056473	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 32)

GO terms by PBA (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005887	integral component of plasma membrane	cellular component	NAS[7665166]	158
GO:0007411	axon guidance	biological process	ISS	60
GO:0005886	plasma membrane	cellular component	ISS	360
GO:0016021	integral component of membrane	cellular component	TAS[10498613]	219
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	molecular function	NAS[7665166]	5

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016328	lateral plasma membrane	cellular component	ISS	7
GO:0000902	cell morphogenesis	biological process	ISS	3
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0043005	neuron projection	cellular component	ISS	38
GO:0003105	negative regulation of glomerular filtration	biological process	ISS	2
GO:0030032	lamellipodium assembly	biological process	ISS	6
GO:0016324	apical plasma membrane	cellular component	ISS	24
GO:0035335	peptidyl-tyrosine dephosphorylation	biological process	IMP[19233845]	9
GO:0090260	negative regulation of retinal ganglion cell axon guidance	biological process	ISS	1
GO:0072112	glomerular visceral epithelial cell differentiation	biological process	ISS	2
GO:0042803	protein homodimerization activity	molecular function	ISS	71
GO:0010977	negative regulation of neuron projection development	biological process	ISS	4
GO:0005515	protein binding	molecular function	IPI[19167335]	563
GO:0017147	Wnt-protein binding	molecular function	ISS	5
GO:0030027	lamellipodium	cellular component	ISS	9
GO:0004725	protein tyrosine phosphatase activity	molecular function	IDA[19167335]; IMP[19233845]; TAS[10498613]	6
GO:0030424	axon	cellular component	ISS	39
GO:0036060	slit diaphragm assembly	biological process	ISS; NAS[20633639]	1
GO:0030426	growth cone	cellular component	ISS	22
GO:0043197	dendritic spine	cellular component	ISS	21
GO:0010812	negative regulation of cell-substrate adhesion	biological process	ISS	1
GO:0032835	glomerulus development	biological process	IMP[21722858]	2
GO:0006470	protein dephosphorylation	biological process	ISS; TAS[10498613]	10
GO:0003093	regulation of glomerular filtration	biological process	ISS	1
GO:0090090	negative regulation of canonical Wnt signaling pathway	biological process	ISS	9
GO:0016791	phosphatase activity	molecular function	ISS	2
GO:0002548	monocyte chemotaxis	biological process	IMP[19233845]	3

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PTPRO	PIM1	NO	in vitro;in vivo	11368509
PTPRO	ACTG1	NO	yeast 2-hybrid	16169070
PTPRO	KIT	NO	in vivo	10397721

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs11056473	chr12:15424795 - 15424795(1)	intron_variant	1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 12	chr12:0-133275309	3 (0/3/0)
12p12	chr12:14600000-26300000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr12:15322397..15597399 View in gBrowse