Gene Report

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Basic Info

Approved Symbol	RAD18
Symbol Alias	RNF73
Approved Name	RAD18 E3 ubiquitin protein ligase
Previous Name	RAD18 homolog (S. cerevisiae)
Location	3p25.3
Position	chr3:8775402-8963773, -1
External Links	HGNC: 18278 Entrez Gene: 56852 Ensembl: ENSG00000070950 UCSC: uc003brd.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
McQuillin, A.,2011		Gene related CNV occurred in two or more cases but not in controls.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	NAS[10884424]	283
GO:0009411	response to UV	biological process	IEA	3

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005657	replication fork	cellular component	IDA[18363965]	2
GO:0031625	ubiquitin protein ligase binding	molecular function	IPI[10908344]	25
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0001741	XY body	cellular component	IEA	1
GO:0000785	chromatin	cellular component	IEA	2
GO:0045910	negative regulation of DNA recombination	biological process	IEA	1
GO:0003684	damaged DNA binding	molecular function	NAS[10884424]	5
GO:0000403	Y-form DNA binding	molecular function	IDA[18363965]	1
GO:0016567	protein ubiquitination	biological process	IEA	18
GO:0031593	polyubiquitin binding	molecular function	IDA[22742833]	3
GO:0007283	spermatogenesis	biological process	IEA	29
GO:0006281	DNA repair	biological process	NAS[10884424]	16
GO:0016874	ligase activity	molecular function	IEA	16
GO:0005515	protein binding	molecular function	IPI[21659603]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
RAD18	UBE2B	NO	in vitro;in vivo;yeast 2-hybrid	10908344 , 10884424 , 17720710 , 18316726
RAD18	UBE2A	NO	in vivo;yeast 2-hybrid	10908344 , 10884424

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_McQuillin[2011]_7	chr3:8896559-8980146 (NCBI Build 36 (hg18))	83588

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
3p25	chr3:8100000-16300000	1 (0/1/0)
Chr 3	chr3:0-198295559	2 (0/2/0)
3p24-p26	chr3:0-30800000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:8775402..8963773 View in gBrowse