Gene Report

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Basic Info

Approved Symbol	TIPIN
Symbol Alias	FLJ20516
Approved Name	TIMELESS interacting protein
Name Alias	CSM3 homolog (S. cerevisiae)
Location	15q22.31
Position	chr15:66336206-66386746, -1
External Links	HGNC: 30750 Entrez Gene: 54962 Ensembl: ENSG00000075131 UCSC: uc002apr.2
No. of Studies	2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Byrne, E. M., 2014		P-value=0.06. Gene-based tests show no significant association between this gene and BD.	Negative	Comment on Study
Mansour, H. A.,2009		Gene-based tests:X<sup>2</sup>=4.334, P-value = 0.184 in dominant model, X<sup>2</sup>=3.796, P-value = 0.209 in additive model, X<sup>2</sup>=1.885, P-value = 0.608 in recessive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0009411	response to UV	biological process	IEA	3
GO:0005634	nucleus	cellular component	IDA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0033262	regulation of nuclear cell cycle DNA replication	biological process	TAS[17102137]	1
GO:0007067	mitotic nuclear division	biological process	IEA	15
GO:0031573	intra-S DNA damage checkpoint	biological process	IMP[17102137]	1
GO:0000790	nuclear chromatin	cellular component	IDA[17102137]	7
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0008284	positive regulation of cell proliferation	biological process	IMP[17102137]	44
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0005794	Golgi apparatus	cellular component	IDA	60
GO:0051301	cell division	biological process	IEA	20
GO:0044770	cell cycle phase transition	biological process	IMP[17102137]	3
GO:0005515	protein binding	molecular function	IPI[17102137]	563
GO:0048478	replication fork protection	biological process	IEA	2
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA	34
GO:0000076	DNA replication checkpoint	biological process	IMP[17102137]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TIPIN	TIMELESS	YES	in vitro;in vivo;yeast 2-hybrid	12875843

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
15q22	chr15:58800000-67200000	2 (0/1/1)
Chr 15	chr15:0-101991189	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19839995	Gene-based tests:X<sup>2</sup>=5.296, P-value = 0.108 in recessive model in SZ/SZA, X<sup>2</sup>=3.515, P-value = 0.237 in additive model in SZ/SZA, X<sup>2</sup>=3.622, P-value = 0.319 in dominant model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
24687905	P-value=0.88. Gene-based tests show no significant association between this gene and SZ.	Negative

Gene relationship with MDD

Reference	Description	Category in MDD
24687905	P-value=0.36. Gene-based tests show no significant association between this gene and MDD.	Negative

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Region: chr15:66336206..66386746 View in gBrowse