Gene Report

Basic Info
Approved Symbol CUX2
Previous Symbol CUTL2
Symbol Alias KIAA0293, CDP2
Approved Name cut-like homeobox 2
Previous Name cut-like 2 (Drosophila)
Location 12q24.12
Position chr12:111034024-111350554, 1
External Links HGNC: 19347
Entrez Gene: 23316
Ensembl: ENSG00000111249
UCSC: uc001tsa.3
No. of Studies 3 (Positive: 1; Negative: 2; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Jacobsen, N. J.,2001(a) Other variant: CUX2_1191C/T, CUX2_2607G/C, CUX2_277G/A, CUX2_3732T/C No evidence was found for the involvement of variants within the CUX2 coding, or 5' UTR sequence in producing susceptibility to bipolar disorder. Negative Comment on Study
Yosifova, A.,2009 SNP: rs3847953, rs933305 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Glaser, B.,2005(b) SNP: rs3847953 In summary, we have provided evidence for association between BPD and polymorphisms in a small region of chromosome 12q23-q24 that includes the 30 end of the gene encoding CUX2 and a hypothetical protein, FLJ32356. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 14)

GO terms by PBA (count: 2)

GO terms by database search (count: 12)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 19)

Literature-origin SNPs (count: 5)

LD-proxies (count: 14)

Gene related CNVs (count: 0)

Gene related other variants (count: 4)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr12:111034024..111350554 View in gBrowse
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