Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	JAM3
Symbol Alias	JAM-C, JAMC
Approved Name	junctional adhesion molecule 3
Location	11q25
Position	chr11:134068925-134152001, 1
External Links	HGNC: 15532 Entrez Gene: 83700 Ensembl: ENSG00000166086 UCSC: uc001qhb.3
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Ollila, H. M.,2009	SNP: rs10791345	It showed no evidence for association with BPI in our study.	Negative	Comment on Study
Moskvina, V.,2009		In BD:Smallest P-value per gene=0.00245, Product of P truncation <=0.01=0.00196, Product of P truncation <=0.001=0.00444. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 29)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0042552	myelination	biological process	IEA	5

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0002250	adaptive immune response	biological process	IEA	5
GO:0002523	leukocyte migration involved in inflammatory response	biological process	IEA	2
GO:0090138	regulation of actin cytoskeleton organization by cell-cell adhesion	biological process	IEA	1
GO:0005923	tight junction	cellular component	IEA	13
GO:0030198	extracellular matrix organization	biological process	TAS	26
GO:0090022	regulation of neutrophil chemotaxis	biological process	IDA[15194813]	1
GO:0005615	extracellular space	cellular component	IDA[20592283]	85
GO:0042803	protein homodimerization activity	molecular function	IEA	71
GO:0007596	blood coagulation	biological process	TAS	44
GO:0043220	Schmidt-Lanterman incisure	cellular component	IEA	1
GO:0002318	myeloid progenitor cell differentiation	biological process	IEA	1
GO:0046982	protein heterodimerization activity	molecular function	IEA	42
GO:0001525	angiogenesis	biological process	IDA[20592283]	20
GO:0050900	leukocyte migration	biological process	TAS	9
GO:0005794	Golgi apparatus	cellular component	IDA	60
GO:0005178	integrin binding	molecular function	IPI[15194813]	8
GO:0001780	neutrophil homeostasis	biological process	IEA	3
GO:0005515	protein binding	molecular function	IPI[21982860]	563
GO:0031103	axon regeneration	biological process	IEA	3
GO:0019226	transmission of nerve impulse	biological process	IEA	7
GO:0044291	cell-cell contact zone	cellular component	IDA[15994945]	2
GO:0007286	spermatid development	biological process	IEA	2
GO:0007160	cell-matrix adhesion	biological process	IEA	11
GO:0030057	desmosome	cellular component	IDA[15194813]	2
GO:0030010	establishment of cell polarity	biological process	IEA	4
GO:0033010	paranodal junction	cellular component	IEA	1

Gene related KEGG pathways (count: 4)

KEGG pathways by PBA (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04530	Tight junction	18
hsa04514	Cell adhesion molecules (CAMs)	14

KEGG pathways by database search (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04670	Leukocyte transendothelial migration	13
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	11

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
JAM3	PICK1	YES	in vivo	15811349
JAM3	JAM2	NO	in vitro;in vivo	11823489
JAM3	TJP1	NO	in vitro;in vivo	12953056
JAM3	ITGAX	NO	in vivo	12208882
JAM3	ITGAM	NO	in vitro;in vivo	12208882
JAM3	F2RL2	NO	in vitro;in vivo	12953056 , 17057644

Related other genetic factors

Gene related SNPs (count: 10)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs10791345	chr11:134142118 - 134142118(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	2(0/1/1)

LD-proxies (count: 9)

rs_ID	Location	Functional Annotation
rs1267746	chr11:134076818 - 134076818(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs654160	chr11:134080723 - 134080723(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs7101690	chr11:134124288 - 134124288(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs10894778	chr11:134125113 - 134125113(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs646763	chr11:134070278 - 134070278(1)	3_prime_UTR_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; splice_region_variant
rs671974	chr11:134075835 - 134075835(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs2276266	chr11:134139965 - 134139965(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs11223704	chr11:134127157 - 134127157(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs11223703	chr11:134125356 - 134125356(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 11	chr11:0-135086622	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
19065143	In SZ:Smallest P-value per gene=0.00396, Product of P truncation <=0.01=0.00213, Product of P truncation <=0.001=0.00112 It showed evidence for association with SZ.	Positive

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

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Region: chr11:134068925..134152001 View in gBrowse