Gene Report

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Basic Info

Approved Symbol	GSS
Approved Name	glutathione synthetase
Location	20q11.2
Position	chr20:34928430-34955817, -1
External Links	HGNC: 4624 Entrez Gene: 2937 Ensembl: ENSG00000100983 UCSC: uc002xbg.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Green, E. K.,2012	SNP: rs2273684	BD ImmunoChip:P-value = 0.00000923,OR = 1.245;ImmunoChip, PGC-BD combined data:P-balue = 0.000000472,OR = 1.119 Suggestive association was found.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007399	nervous system development	biological process	TAS[8896573]	40

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006520	cellular amino acid metabolic process	biological process	TAS[8896573]	5
GO:0004363	glutathione synthase activity	molecular function	TAS	1
GO:0005524	ATP binding	molecular function	IDA[10369661]	118
GO:1901687	glutathione derivative biosynthetic process	biological process	TAS	6
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0007568	aging	biological process	IEA	22
GO:0034612	response to tumor necrosis factor	biological process	IEA	3
GO:0031667	response to nutrient levels	biological process	IEA	7
GO:0043295	glutathione binding	molecular function	IDA[10369661]	2
GO:0006805	xenobiotic metabolic process	biological process	TAS	19
GO:0046686	response to cadmium ion	biological process	IEA	3
GO:0005829	cytosol	cellular component	TAS	223
GO:0006750	glutathione biosynthetic process	biological process	IEA; TAS	3
GO:0016594	glycine binding	molecular function	IEA	6
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0042803	protein homodimerization activity	molecular function	IDA[10369661]	71
GO:0043200	response to amino acid	biological process	IEA	6
GO:0006979	response to oxidative stress	biological process	TAS[465367]	11
GO:0000287	magnesium ion binding	molecular function	IDA[10369661]	11

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in BDgene
hsa01510	Neurodegenerative Diseases	10
hsa05060	Prion disease	7
hsa00251	Glutamate metabolism	5
hsa00480	Glutathione metabolism	8

Gene related BioCarta pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
freePathway	Free Radical Induced Apoptosis	2

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
GSS	GSTZ1	YES	in vitro	15173170

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2273684	chr20:34941963 - 34941963(1)	intron_variant	1(0/0/1)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs13041792		chr20:34957252 - 34957252(1)	upstream_gene_variant
rs6088662		chr20:34959830 - 34959830(1)	upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 20	chr20:0-64444167	4 (0/3/1)
20p11-q13	chr20:17900000-64444167	1 (1/0/0)
20q11	chr20:28100000-39000000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
16909399	32	Positive

Gene relationship with MDD

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Region: chr20:34928430..34955817 View in gBrowse