Gene Report

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Basic Info

Approved Symbol	ADORA2B
Approved Name	adenosine A2b receptor
Location	17p12
Position	chr17:15944917-15975746, 1
External Links	HGNC: 264 Entrez Gene: 136 Ensembl: ENSG00000170425 UCSC: uc002gpd.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gratacos, M.,2009	SNP: rs758857	Nominal associations with bipolar disorder was observed.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005887	integral component of plasma membrane	cellular component	TAS[7558011]	158

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0031284	positive regulation of guanylate cyclase activity	biological process	IEA	4
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[7558011]	64
GO:0007190	activation of adenylate cyclase activity	biological process	TAS[8022409]	12
GO:0032722	positive regulation of chemokine production	biological process	IEA	4
GO:0031668	cellular response to extracellular stimulus	biological process	IEA	4
GO:0002882	positive regulation of chronic inflammatory response to non-antigenic stimulus	biological process	IEA	1
GO:0010575	positive regulation vascular endothelial growth factor production	biological process	IEA	5
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	biological process	IEA	11
GO:0006968	cellular defense response	biological process	TAS[10101031]	4
GO:0007254	JNK cascade	biological process	TAS[10101031]	8
GO:0001973	adenosine receptor signaling pathway	biological process	IEA	2
GO:0000187	activation of MAPK activity	biological process	TAS[10101031]	14
GO:0043306	positive regulation of mast cell degranulation	biological process	IEA	2
GO:0032755	positive regulation of interleukin-6 production	biological process	IEA	8
GO:0007588	excretion	biological process	TAS[7836474]	4
GO:0001609	G-protein coupled adenosine receptor activity	molecular function	IEA	1
GO:0060087	relaxation of vascular smooth muscle	biological process	IEA	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04020	Calcium signaling pathway	53

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ADORA2B	ADA	NO	in vitro;in vivo	11125033
ADORA2B	EZR	NO	in vitro;in vivo	12080047
ADORA2B	SLC9A3R2	NO	in vitro	12080047
ADORA2B	DCC	YES	in vitro;in vivo;yeast 2-hybrid	11048721
ADORA2B	NTN1	NO	in vitro;in vivo	11048721

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs758857	chr17:15950943 - 15950943(1)	intron_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
17p13.1-17p12	chr17:6500000-16100000	1 (0/1/0)
17p12-q21.33	chr17:10800000-52100000	1 (0/1/0)
17p12	chr17:10800000-16100000	2 (0/1/1)
Chr 17	chr17:0-83257441	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr17:15944917..15975746 View in gBrowse