Gene Report

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Basic Info

Approved Symbol	GRID1
Symbol Alias	GluD1, KIAA1220
Approved Name	glutamate receptor, ionotropic, delta 1
Location	10q22
Position	chr10:85599555-86366493, -1
External Links	HGNC: 4575 Entrez Gene: 2894 Ensembl: ENSG00000182771 UCSC: uc001kdl.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		29 SNP typed, Median D'=0.21, Median r<sup>2</sup> =0.01, 13 LD blocks, 0.31 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in SZ and P-value > 0.01 and <0.05 in BP and SZ/SZA.. This gene is highly suggestive to SZ and suggestive to BP.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004970	ionotropic glutamate receptor activity	molecular function	IBA	2
GO:0045211	postsynaptic membrane	cellular component	IBA	68
GO:0005234	extracellular-glutamate-gated ion channel activity	molecular function	IBA	12

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0035249	synaptic transmission, glutamatergic	biological process	IBA	14
GO:0030054	cell junction	cellular component	IEA	88
GO:0034220	ion transmembrane transport	biological process	IBA	50
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0035176	social behavior	biological process	ISS	17
GO:0008328	ionotropic glutamate receptor complex	cellular component	IBA	6
GO:0035235	ionotropic glutamate receptor signaling pathway	biological process	IBA	13
GO:0030425	dendrite	cellular component	IBA	65

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
GRID1	GOPC	NO	in vivo;yeast 2-hybrid	12372286
GRID1	EML1	YES	in vitro;in vivo;yeast 2-hybrid	11829466
GRID1	DLG2	YES	yeast 2-hybrid	10234023

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10q22.3-23.32	chr10:75900000-92300000	1 (0/1/0)
10q22.1-q24.1	chr10:68800000-97500000	1 (1/0/0)
10q22.3-24.1	chr10:75900000-97500000	1 (0/1/0)
Chr 10	chr10:0-133797422	3 (0/2/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is highly suggestive to SZ and suggestive to BP.	Positive

Gene relationship with MDD

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Region: chr10:85599555..86366493 View in gBrowse