Gene Report

Approved Symbol	RFX4
Approved Name	regulatory factor X, 4 (influences HLA class II expression)
Location	12q24
Position	chr12:106582907-106762803, 1
External Links	HGNC: 9985 Entrez Gene: 5992 Ensembl: ENSG00000111783 UCSC: uc001tlt.3
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Yosifova, A.,2009	SNP: rs10778502	No SNP of this gene had significant association with BD in our population.	Negative	Comment on Study
Glaser, B.,2005(a)	Haplotype: rs10778502 - ss24735177(), rs10778502 - ss24735177 - D12S2072() Other variant: RFX4_D12S2072	In conclusion, the current study demonstrates the association of BPD with a haplotype at RFX4 derived from marker rs10778502 and ss24735177. Investigation of RFX4 brain cDNA tagged by rs10778502 provided evidence for significant differences in allelic expression, which might be modulated through variation at ss24735177.	Positive	Comment on Study

Region: chr12:106582907..106762803 View in gBrowse