Gene Report

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Basic Info

Approved Symbol	DOK5
Previous Symbol	C20orf180
Symbol Alias	dJ805C22.1
Approved Name	docking protein 5
Previous Name	chromosome 20 open reading frame 180
Location	20q13.2
Position	chr20:54475597-54651171, 1
External Links	HGNC: 16173 Entrez Gene: 55816 Ensembl: ENSG00000101134 UCSC: uc002xwy.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Liu, X.,2010	SNP: rs2023454	Although preliminary, these data suggest that DOK5 and perhaps several other genes influence the magnitude of amygdala activation during face processing, particularly in those with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005158	insulin receptor binding	molecular function	IEA	5
GO:0007399	nervous system development	biological process	IEA	40

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological process	IEA	16
GO:0000165	MAPK cascade	biological process	IEA	10
GO:0005057	receptor signaling protein activity	molecular function	IEA	7

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DOK5	INSR	NO	in vivo	12730241
DOK5	CCDC85B	NO	yeast 2-hybrid	16189514
DOK5	BNIP3L	YES	yeast 2-hybrid	16189514
DOK5	NTRK3	YES	in vitro;yeast 2-hybrid	16647839
DOK5	IGF1R	NO	in vivo	12730241
DOK5	RET	NO	in vitro;in vivo;yeast 2-hybrid	11470823

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2023454	chr20:54650572 - 54650572(1)	3_prime_UTR_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 20	chr20:0-64444167	4 (0/3/1)
20p11-q13	chr20:17900000-64444167	1 (1/0/0)
20q13	chr20:43100000-64444167	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr20:54475597..54651171 View in gBrowse