Gene Report

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Basic Info

Approved Symbol	CYTH4
Previous Symbol	PSCD4
Symbol Alias	CYT4, cytohesin-4
Approved Name	cytohesin 4
Previous Name	pleckstrin homology, Sec7 and coiled/coil domains 4, "pleckstrin homology, Sec7 and coiled-coil domains 4"
Location	22q12.3-q13.1
Position	chr22:37282027-37315345, 1
External Links	HGNC: 9505 Entrez Gene: 27128 Ensembl: ENSG00000100055 UCSC: uc003arf.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Rezazadeh, M., 2014	Other variant: CYTH4_Promoter (GTTT)n	STR variation in the core promoter of this gene showed association with type I BD	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IDA[17398095]	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005086	ARF guanyl-nucleotide exchange factor activity	molecular function	IBA; IDA[10652308]	1
GO:0043547	positive regulation of GTPase activity	biological process	IBA; IDA[10652308]; IEA	30
GO:0005802	trans-Golgi network	cellular component	IBA	10
GO:0030155	regulation of cell adhesion	biological process	IBA	3
GO:0008289	lipid binding	molecular function	IEA	8
GO:0016192	vesicle-mediated transport	biological process	IBA	10

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
arapPathway	ADP-Ribosylation Factor	1

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
CYTH4_Promoter (GTTT)n	STR	Promoter	1 (1/0/0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
22q12.3-13.32	chr22:31800000-49100000	1 (0/1/0)
Chr 22	chr22:0-50818468	2 (0/1/1)
22q12.3-q13.33	chr22:31800000-50818468	1 (1/0/0)
22q13	chr22:37200000-50818468	1 (1/0/0)
22q13.1	chr22:37200000-40600000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr22:37282027..37315345 View in gBrowse