Gene Report

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Basic Info

Approved Symbol	GRIK5
Previous Symbol	GRIK2
Symbol Alias	GluK5, KA2
Approved Name	glutamate receptor, ionotropic, kainate 5
Location	19q13.2
Position	chr19:41998321-42069498, -1
External Links	HGNC: 4583 Entrez Gene: 2901 Ensembl: ENSG00000105737 UCSC: uc002osj.2
No. of Studies	2 (Positive: 1; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Yosifova, A.,2011	SNP: rs8099939	Suggestive association of this gene was found.	Trend	Comment on Study
Gratacos, M.,2009	SNP: rs10414815	Strong associations of GRIK5 to bipolar disorder have been identifiedã€‚	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007268	synaptic transmission	biological process	TAS	116
GO:0030165	PDZ domain binding	molecular function	IEA	16
GO:0005234	extracellular-glutamate-gated ion channel activity	molecular function	IBA	12
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0045211	postsynaptic membrane	cellular component	IBA	68
GO:0015277	kainate selective glutamate receptor activity	molecular function	IDA[1321949]	4

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0042734	presynaptic membrane	cellular component	IBA	16
GO:0005783	endoplasmic reticulum	cellular component	IEA	49
GO:0006621	protein retention in ER lumen	biological process	IEA	1
GO:0030425	dendrite	cellular component	IBA	65
GO:0014069	postsynaptic density	cellular component	IEA	26
GO:0043204	perikaryon	cellular component	IEA	17
GO:0042802	identical protein binding	molecular function	IEA	44
GO:0043195	terminal bouton	cellular component	IEA	17
GO:0017124	SH3 domain binding	molecular function	IEA	11
GO:0035249	synaptic transmission, glutamatergic	biological process	IBA	14
GO:0071333	cellular response to glucose stimulus	biological process	IEA	7
GO:0035235	ionotropic glutamate receptor signaling pathway	biological process	IDA[1321949]; IEA	13
GO:0031630	regulation of synaptic vesicle fusion to presynaptic membrane	biological process	IEA	1
GO:0032983	kainate selective glutamate receptor complex	cellular component	IBA	4
GO:0030054	cell junction	cellular component	IEA	88
GO:0043113	receptor clustering	biological process	IEA	8
GO:0034220	ion transmembrane transport	biological process	IBA; IEA	50
GO:0043525	positive regulation of neuron apoptotic process	biological process	IEA	11
GO:0060079	regulation of excitatory postsynaptic membrane potential	biological process	IEA	10
GO:0051649	establishment of localization in cell	biological process	IEA	2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
GRIK5	GPAA1	NO	yeast 2-hybrid	16169070
GRIK5	GRID2	NO	in vivo	12573530
GRIK5	LRSAM1	NO	yeast 2-hybrid	16169070
GRIK5	GOLM1	NO	yeast 2-hybrid	16169070
GRIK5	DLG4	NO	in vitro;in vivo	9808460 , 11279111
GRIK5	MLF1	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs10414815	chr19:42082093 - 42082093(1)	downstream_gene_variant	1(1/0/0)
rs2852571	chr6:101554216 - 101554216(1)	intron_variant	1(0/1/0)
rs8099939	chr19:42016956 - 42016956(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
19p13-q13	chr19:0-58617616	1 (0/1/0)
Chr 19	chr19:0-58617616	2 (0/2/0)
19q13	chr19:31900000-58617616	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
16325263	191	Negative

Gene relationship with MDD

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Region: chr19:41998321..42069498 View in gBrowse