Gene Report

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Basic Info

Approved Symbol	OR5AS1
Approved Name	olfactory receptor, family 5, subfamily AS, member 1
Location	11q11
Position	chr11:56030419-56031393, 1
External Links	HGNC: 15261 Entrez Gene: 219447 Ensembl: ENSG00000181785 UCSC: uc010riw.2
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs142890517	Amish-specific putative damaging exonic missense variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005887	integral component of plasma membrane	cellular component	IBA	158

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004930	G-protein coupled receptor activity	molecular function	IBA	26
GO:0004984	olfactory receptor activity	molecular function	IBA	5
GO:0005549	odorant binding	molecular function	IBA	1
GO:0007608	sensory perception of smell	biological process	IBA	8
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IBA	64
GO:0050911	detection of chemical stimulus involved in sensory perception of smell	biological process	IBA; IEA	5

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04740	Olfactory transduction	11

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs142890517	chr11:56030938 - 56030938(1)	missense_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
11q12.1	chr11:55800000-60100000	1 (0/0/1)
Chr 11	chr11:0-135086622	2 (0/2/0)
11q14.3-11q21	chr11:22000000-97400000	1 (0/0/1)
11p13-q13.3	chr11:31000000-70500000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr11:56030419..56031393 View in gBrowse