Gene Report

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Basic Info

Approved Symbol	DDX18
Symbol Alias	MrDb
Approved Name	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
Previous Name	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 18 (Myc-regulated)
Location	2q21.2
Position	chr2:117814650-117832379, 1
External Links	HGNC: 2741 Entrez Gene: 8886 Ensembl: ENSG00000088205 UCSC: uc002tlh.1
No. of Studies	2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Djurovic, S.,2010	SNP: rs12052834, rs1472779, rs4257412	No significant association of this gene was observed in BD.	Negative	Comment on Study
Gonzalez, S., 2014	SNP: rs1516003	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016020	membrane	cellular component	IDA[19946888]	137

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005524	ATP binding	molecular function	IEA	118
GO:0005515	protein binding	molecular function	IPI[16963496]	563
GO:0005730	nucleolus	cellular component	IDA	28
GO:0008152	metabolic process	biological process	IEA; TAS[8861962]	50
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674]	44
GO:0004004	ATP-dependent RNA helicase activity	molecular function	TAS[8861962]	4

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00790	Folate biosynthesis	7
hsa00500	Starch and sucrose metabolism	5

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DDX18	MTA1	NO	yeast 2-hybrid	16169070
DDX18	INADL	NO	yeast 2-hybrid	16169070
DDX18	CRMP1	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 4)

rs_ID	Location	No. of Studies (Positive/Negative/Trend)
rs1516003	chr2:117576666 - 117576666(1)	1(0/1/0)
rs12052834	chr2:116330424 - 116330424(1)	1(0/1/0)
rs4257412	chr2:116367087 - 116367087(1)	1(0/1/0)
rs1472779	chr2:116378222 - 116378222(1)	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q12.3-q22.1	chr2:106700000-141500000	1 (0/1/0)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p11-q14	chr2:83100000-129100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:117814650..117832379 View in gBrowse