BDgene

Gene Report

Basic Info
Approved Symbol CHRNA2
Approved Name cholinergic receptor, nicotinic, alpha 2 (neuronal)
Previous Name cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)
Name Alias acetylcholine receptor, nicotinic, alpha 2 (neuronal)
Location 8p21
Position chr8:27459761-27479883, -1
External Links HGNC: 1956
Entrez Gene: 1135
Ensembl: ENSG00000120903
UCSC: uc010lur.3
No. of Studies 3 (Positive: 0; Negative: 3; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Shi, J., 2007 SNP: rs2741335, rs2741339, rs7017417, rs891397, rs9314347
Haplotype: rs9314347 - rs891397(G-C)
no evidence of interaction among these 19 cholinergic genes was found by Allelic Association, Haploview Tests, FITF analysis and FDR correction Negative Comment on Study
Fallin, M. D.,2005 4 SNP typed, Median D'=0.94, Median r<sup>2</sup> =0.1, 3 LD blocks, 0.01 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. Negative Comment on Study
Lohoff, F. W.,2005(b) SNP: rs2292977, rs2565055, rs2565065, rs735421, rs748281, rs891398
Haplotype: rs2565055 - rs2565065 - rs891398 - rs735421 - rs2292977 - rs748281(G-A-T-A-G-C), rs2565055 - rs2565065 - rs891398 - rs735421 - rs2292977 - rs748281(G-G-C-A-C-T), rs2565055 - rs2565065 - rs891398 - rs735421 - rs2292977 - rs748281(G-G-C-A-G-C), rs2565055 - rs2565065 - rs891398 - rs735421 - rs2292977 - rs748281(G-G-C-G-G-C), rs2565055 - rs2565065 - rs891398 - rs735421 - rs2292977 - rs748281(G-G-T-A-G-C), rs2565055 - rs2565065 - rs891398 - rs735421 - rs2292977 - rs748281(T-G-C-A-G-C), rs2565055 - rs2565065 - rs891398 - rs735421 - rs2292977 - rs748281(T-G-C-G-G-C)
In summary, we showed that common variations in the CHRNA2 gene are not associated with bipolar I disorder in this group of patients and controls. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 15)

GO terms by PBA (count: 6)

GO terms by database search (count: 9)


Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 34)

Literature-origin SNPs (count: 11)

LD-proxies (count: 23)


Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 2)


Gene relationship with MDD

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Region: chr8:27459761..27479883 View in gBrowse
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