Gene Report

Approved Symbol	CHRNA2
Approved Name	cholinergic receptor, nicotinic, alpha 2 (neuronal)
Previous Name	cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)
Name Alias	acetylcholine receptor, nicotinic, alpha 2 (neuronal)
Location	8p21
Position	chr8:27459761-27479883, -1
External Links	HGNC: 1956 Entrez Gene: 1135 Ensembl: ENSG00000120903 UCSC: uc010lur.3
No. of Studies	3 (Positive: 0; Negative: 3; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Shi, J., 2007	SNP: rs2741335, rs2741339, rs7017417, rs891397, rs9314347 Haplotype: rs9314347 - rs891397(G-C)	no evidence of interaction among these 19 cholinergic genes was found by Allelic Association, Haploview Tests, FITF analysis and FDR correction	Negative	Comment on Study
Fallin, M. D.,2005		4 SNP typed, Median D'=0.94, Median r<sup>2</sup> =0.1, 3 LD blocks, 0.01 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP.	Negative	Comment on Study
Lohoff, F. W.,2005(b)	SNP: rs2292977, rs2565055, rs2565065, rs735421, rs748281, rs891398 Haplotype: rs2565055 - rs2565065 - rs891398 - rs735421 - rs2292977 - rs748281(G-A-T-A-G-C), rs2565055 - rs2565065 - rs891398 - rs735421 - rs2292977 - rs748281(G-G-C-A-C-T), rs2565055 - rs2565065 - rs891398 - rs735421 - rs2292977 - rs748281(G-G-C-A-G-C), rs2565055 - rs2565065 - rs891398 - rs735421 - rs2292977 - rs748281(G-G-C-G-G-C), rs2565055 - rs2565065 - rs891398 - rs735421 - rs2292977 - rs748281(G-G-T-A-G-C), rs2565055 - rs2565065 - rs891398 - rs735421 - rs2292977 - rs748281(T-G-C-A-G-C), rs2565055 - rs2565065 - rs891398 - rs735421 - rs2292977 - rs748281(T-G-C-G-G-C)	In summary, we showed that common variations in the CHRNA2 gene are not associated with bipolar I disorder in this group of patients and controls.	Negative	Comment on Study

Region: chr8:27459761..27479883 View in gBrowse