Gene Report

Basic Info
Approved Symbol GRIK3
Symbol Alias GluK3, GLUR7
Approved Name glutamate receptor, ionotropic, kainate 3
Location 1p34.3
Position chr1:36795527-37034129, -1
External Links HGNC: 4581
Entrez Gene: 2899
Ensembl: ENSG00000163873
UCSC: uc001caz.2
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Schiffer, H. H., 2007 TDT <sub>linkage</sub> P-value = 0.698, RR (95% CI)=1.1(0.8-1.5) for bipolar I disorder; TDT <sub>linkage</sub> P-value = 0.020, RR (95% CI)=1.9(1.1-3.2) for Bipolar II disorder. The TDT analysis of the BP families (NIMH study) also found evidence that the GluR7 G allele is maternally linked and associated to BPII, but not BPI. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 25)

GO terms by PBA (count: 7)

GO terms by database search (count: 18)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 7)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr1:36795527..37034129 View in gBrowse
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