Gene Report

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Basic Info

Approved Symbol	GRIK3
Symbol Alias	GluK3, GLUR7
Approved Name	glutamate receptor, ionotropic, kainate 3
Location	1p34.3
Position	chr1:36795527-37034129, -1
External Links	HGNC: 4581 Entrez Gene: 2899 Ensembl: ENSG00000163873 UCSC: uc001caz.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Schiffer, H. H., 2007		TDT <sub>linkage</sub> P-value = 0.698, RR (95% CI)=1.1(0.8-1.5) for bipolar I disorder; TDT <sub>linkage</sub> P-value = 0.020, RR (95% CI)=1.9(1.1-3.2) for Bipolar II disorder. The TDT analysis of the BP families (NIMH study) also found evidence that the GluR7 G allele is maternally linked and associated to BPII, but not BPI.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045211	postsynaptic membrane	cellular component	IBA	68
GO:0005887	integral component of plasma membrane	cellular component	IDA[7719709]	158
GO:0005234	extracellular-glutamate-gated ion channel activity	molecular function	IBA	12
GO:0007268	synaptic transmission	biological process	TAS	116
GO:0004970	ionotropic glutamate receptor activity	molecular function	IDA[11124978]; ISS	2
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0015277	kainate selective glutamate receptor activity	molecular function	IDA[7719709]	4

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043204	perikaryon	cellular component	ISS	17
GO:0035235	ionotropic glutamate receptor signaling pathway	biological process	IDA[11124978]; IEA; ISS	13
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	biological process	IDA[9144652]	5
GO:0042391	regulation of membrane potential	biological process	IDA[11124978]; ISS	13
GO:0035249	synaptic transmission, glutamatergic	biological process	IBA	14
GO:0030054	cell junction	cellular component	IEA	88
GO:0043195	terminal bouton	cellular component	ISS	17
GO:0007215	glutamate receptor signaling pathway	biological process	IDA[7719709]	7
GO:0034220	ion transmembrane transport	biological process	IBA; IEA	50
GO:0030425	dendrite	cellular component	IBA; ISS	65
GO:0030424	axon	cellular component	ISS	39
GO:0032983	kainate selective glutamate receptor complex	cellular component	IBA	4
GO:0032839	dendrite cytoplasm	cellular component	ISS	2
GO:0007216	G-protein coupled glutamate receptor signaling pathway	biological process	IDA[9144652]	1
GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity	molecular function	IDA[9144652]	1
GO:0042734	presynaptic membrane	cellular component	IBA	16
GO:0051967	negative regulation of synaptic transmission, glutamatergic	biological process	ISS	5
GO:0008066	glutamate receptor activity	molecular function	TAS[8128318]	6

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
GRIK3	FLNA	NO	in vivo	11943148
GRIK3	GRIK5	YES	in vivo	9466455

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Sheng[2012]_5	chr1:37006017-37299068 (Affymetrix SNP 6.0 array reference genome)	293051	1p34

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p33-p36	chr1:0-50200000	1 (0/0/1)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Reference	Description	Category in MDD
16958029	TDT <sub>linkage</sub> P-value = 0.011, RR (95% CI)=2.1(1.2-3.8) in NIMH study; TDT <sub>linkage</sub> P-value = 0.629, RR (95% CI)=1.1(0.5-2.6) in pittsburgh study. Combined TDT <sub>linkage</sub> P-value = 0.066, RR (95% CI)=1.3(0.7-2.6). We detected a significant linkage disequilibrium (LD) indicated by preferential maternal transmission of the GluR7 S310 allele to R-MDD patients. We performed a second independent study by applying the TDT in 81 parent-offspring triads from families that inherit recurrent early-onset major depressive disorder (RE-MDD). The results from this second study showed only a suggestive maternal association	Positive

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Region: chr1:36795527..37034129 View in gBrowse