Gene Report

Basic Info
Approved Symbol TENM4
Previous Symbol ODZ4
Symbol Alias KIAA1302, Ten-M4
Approved Name teneurin transmembrane protein 4
Previous Name odz, odd Oz/ten-m homolog 4 (Drosophila)
Location 11q13
Position chr11:78652831-79440948, -1
External Links HGNC: 29945
Entrez Gene: 26011
Ensembl: ENSG00000149256
UCSC: uc001ozl.4
No. of Studies 6 (Positive: 4; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 6)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Green, E. K.,2012 SNP: rs12576775 BD ImmunoChip:P-value = 0.047,OR = 0.887;ImmunoChip, PGC-BD combined data:P-balue = 0.0000000062,OR = 0.881 The SNP showed a significant association with BD. Positive Comment on Study
Cross-Disorder Group of the Psychiatric Genomics Consortium,2013 SNP: rs12576775 Significant association was observed in BPD. Positive Comment on Study
Huang, J.,2010 SNP: rs11237798 No significant association of this gene was observed in BD. Negative Comment on Study
Chen, D. T.,2011 SNP: rs17138171 No significant association was observed. Negative Comment on Study
Muhleisen, T. W., 2014 SNP: rs12290811, rs12576775, rs7932890, rs17138171, rs11237799 Our second most significant locus was marked by 10 genome-wide significant SNPs in ODZ4. Positive Comment on Study
Sklar, P.,2011 SNP: rs12576775, rs2175420 Significant association was found . Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 15)

GO terms by PBA (count: 2)

GO terms by database search (count: 13)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 28)

Literature-origin SNPs (count: 9)

LD-proxies (count: 19)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr11:78652831..79440948 View in gBrowse
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