Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	TENM4
Previous Symbol	ODZ4
Symbol Alias	KIAA1302, Ten-M4
Approved Name	teneurin transmembrane protein 4
Previous Name	odz, odd Oz/ten-m homolog 4 (Drosophila)
Location	11q13
Position	chr11:78652831-79440948, -1
External Links	HGNC: 29945 Entrez Gene: 26011 Ensembl: ENSG00000149256 UCSC: uc001ozl.4
No. of Studies	6 (Positive: 4; Negative: 2; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 6)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Green, E. K.,2012	SNP: rs12576775	BD ImmunoChip:P-value = 0.047,OR = 0.887;ImmunoChip, PGC-BD combined data:P-balue = 0.0000000062,OR = 0.881 The SNP showed a significant association with BD.	Positive	Comment on Study
Cross-Disorder Group of the Psychiatric Genomics Consortium,2013	SNP: rs12576775	Significant association was observed in BPD.	Positive	Comment on Study
Huang, J.,2010	SNP: rs11237798	No significant association of this gene was observed in BD.	Negative	Comment on Study
Chen, D. T.,2011	SNP: rs17138171	No significant association was observed.	Negative	Comment on Study
Muhleisen, T. W., 2014	SNP: rs12290811, rs12576775, rs7932890, rs17138171, rs11237799	Our second most significant locus was marked by 10 genome-wide significant SNPs in ODZ4.	Positive	Comment on Study
Sklar, P.,2011	SNP: rs12576775, rs2175420	Significant association was found .	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 15)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	ISS	283
GO:0005887	integral component of plasma membrane	cellular component	IEA	158

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:2000543	positive regulation of gastrulation	biological process	ISS	2
GO:0001702	gastrulation with mouth forming second	biological process	IEA	1
GO:0043005	neuron projection	cellular component	ISS	38
GO:0060038	cardiac muscle cell proliferation	biological process	IEA	2
GO:0097264	self proteolysis	biological process	IEA	2
GO:0060912	cardiac cell fate specification	biological process	IEA	1
GO:0042803	protein homodimerization activity	molecular function	ISS	71
GO:0032289	central nervous system myelin formation	biological process	ISS	1
GO:0007165	signal transduction	biological process	IEA	136
GO:0048666	neuron development	biological process	IEA	7
GO:0005737	cytoplasm	cellular component	ISS	322
GO:0031643	positive regulation of myelination	biological process	ISS	1
GO:0048714	positive regulation of oligodendrocyte differentiation	biological process	ISS	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 28)

Literature-origin SNPs (count: 9)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs17138171	chr11:79351885 - 79351885(1)	intron_variant; non_coding_transcript_variant	2(1/1/0)
rs12576775	chr11:79366149 - 79366149(1)	intron_variant; non_coding_transcript_variant	4(4/0/0)
rs11237799	chr11:79356427 - 79356427(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)
rs12290811	chr11:79372576 - 79372576(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)
rs7932890	chr11:79357349 - 79357349(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)
rs17138230	chr11:79364808 - 79364808(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)
rs11237798	chr11:79353537 - 79353537(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs7108878	chr11:79396763 - 79396763(1)	intron_variant; non_coding_transcript_variant	1(0/0/1)
rs2175420	chr11:79412839 - 79412839(1)	intron_variant; non_coding_transcript_variant	1(0/0/1)

LD-proxies (count: 19)

rs_ID	Location	Functional Annotation
rs12289486	chr11:79381483 - 79381483(1)	intron_variant; non_coding_transcript_variant
rs10501439	chr11:79374802 - 79374802(1)	intron_variant; non_coding_transcript_variant
rs11237821	chr11:79395760 - 79395760(1)	intron_variant; non_coding_transcript_variant
rs12577328	chr11:79382430 - 79382430(1)	intron_variant; non_coding_transcript_variant
rs12279388	chr11:79356629 - 79356629(1)	intron_variant; non_coding_transcript_variant
rs954129	chr11:79349751 - 79349751(1)	intron_variant; non_coding_transcript_variant
rs1944449	chr11:79372205 - 79372205(1)	intron_variant; non_coding_transcript_variant
rs11237805	chr11:79367625 - 79367625(1)	intron_variant; non_coding_transcript_variant
rs11237796	chr11:79348399 - 79348399(1)	intron_variant; non_coding_transcript_variant
rs12577093	chr11:79346052 - 79346052(1)	intron_variant; non_coding_transcript_variant
rs10501444	chr11:79426334 - 79426334(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs17138318	chr11:79421039 - 79421039(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs12275195	chr11:79394755 - 79394755(1)	intron_variant; non_coding_transcript_variant
rs11237820	chr11:79393621 - 79393621(1)	intron_variant; non_coding_transcript_variant
rs12277834	chr11:79389112 - 79389112(1)	intron_variant; non_coding_transcript_variant
rs12273727	chr11:79418572 - 79418572(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs12279943	chr11:79418882 - 79418882(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs1567540	chr11:79413040 - 79413040(1)	intron_variant; non_coding_transcript_variant
rs12275848	chr11:79416285 - 79416285(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
11q14.1	chr11:77400000-85900000	2 (1/0/1)
11q14.1-14.3	chr11:77400000-93000000	1 (0/1/0)
11q14-q21	chr11:77100000-92800000	1 (0/1/0)
Chr 11	chr11:0-135086622	2 (0/2/0)
11q14.3-11q21	chr11:22000000-97400000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Reference	Description	Result Category
23453885
20713499	No significant association of this gene was observed in SZ.	Negative

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Reference	Description	Category in MDD
20713499	No significant association was observed in MDD.	Negative
23453885

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr11:78652831..79440948 View in gBrowse