Gene Report

Approved Symbol	FKBP5
Symbol Alias	FKBP51, FKBP54, PPIase, P54, Ptg-10
Approved Name	FK506 binding protein 5
Previous Name	FK506-binding protein 5
Location	6p21.31
Position	chr6:35573585-35728583, -1
External Links	HGNC: 3721 Entrez Gene: 2289 Ensembl: ENSG00000096060 UCSC: uc003okx.2
No. of Studies	5 (Positive: 1; Negative: 4; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Willour, V. L.,2009	SNP: rs1043805, rs1360780, rs3798346, rs3800373, rs4713902, rs6912833, rs7757037, rs9296158, rs9380525	In conclusion, common variants of FKBP5 were associated with bipolar disorder and with a feature of illness, number of depressive episodes, implicated in a prior study of depression.	Positive	Comment on Study
Szczepankiewicz A., 2014	SNP: rs1360780, rs755658, rs9470080, rs4713916, rs7748266, rs9296158, rs9394309, rs3800373 Haplotype: rs1360780 - rs755658 - rs9470080 - rs7748266 - rs9296158 - rs9394309 - rs3800373(A-C-G-C-C-A-C), rs1360780 - rs755658 - rs9470080 - rs7748266 - rs9296158 - rs9394309 - rs3800373(C-C-A-T-T-G-T), rs1360780 - rs755658 - rs9470080 - rs7748266 - rs9296158 - rs9394309 - rs3800373(C-T-A-C-T-G-T), rs1360780 - rs755658 - rs9470080 - rs7748266 - rs9296158 - rs9394309 - rs3800373(A-C-G-C-C-G-T), rs1360780 - rs755658 - rs9470080 - rs7748266 - rs9296158 - rs9394309 - rs3800373(C-C-A-C-T-A-T), rs1360780 - rs755658 - rs9470080 - rs7748266 - rs9296158 - rs9394309 - rs3800373(C-C-A-C-T-G-T), rs1360780 - rs755658 - rs9470080 - rs7748266 - rs9296158 - rs9394309 - rs3800373(A-C-A-T-T-G-T)	Our main finding is an association of FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depression but nor with bipolar disorder.	Negative	Comment on Study
Ceulemans, S.,2011	SNP: rs13192954, rs1334894, rs1360780, rs17542466, rs17614642, rs2143404, rs2294807, rs3777747, rs3798346, rs3800374, rs4713899, rs4713902, rs6912833, rs737054, rs755658, rs7757037, rs9296157, rs9296158, rs9366890, rs9380524, rs9470080, rs992105	No significant associations were detected in BD patients.	Negative	Comment on Study
Fallin, M. D.,2005		5 SNP typed, Median D'=1, Median r<sup>2</sup> =0.58, 1 LD blocks, 0.34 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP.	Negative	Comment on Study
Gawlik, M., 2006	SNP: rs1360780, rs3800373, rs4713916 Haplotype: rs4713916 - rs1360780 - rs3800373(G-C-T), rs4713916 - rs1360780 - rs3800373(A-T-G), rs4713916 - rs1360780 - rs3800373(A-C-T), rs4713916 - rs1360780 - rs3800373(G-T-G), rs4713916 - rs1360780 - rs3800373(A-T-T), rs4713916 - rs1360780 - rs3800373(G-T-T), rs4713916 - rs1360780 - rs3800373(G-C-G), rs4713916 - rs1360780 - rs3800373(A-C-G)	Our data do not support a significant genetic contribution of FKBP5 polymorphisms and haplotypes to affective psychosis, and the findings are inconclusive regarding their contribution to disease-related traits.	Negative	Comment on Study

Region: chr6:35573585..35728583 View in gBrowse