Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	PTPRE
Symbol Alias	PTPE
Approved Name	protein tyrosine phosphatase, receptor type, E
Location	10q26
Position	chr10:127907061-128085855, 1
External Links	HGNC: 9669 Entrez Gene: 5791 Ensembl: ENSG00000132334 UCSC: uc001lkb.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BP:Smallest P-value per gene=0.00242, Product of P truncation <=0.01=0.00253, Product of P truncation <=0.001=0.00069. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	molecular function	TAS[2170109]	5
GO:0005634	nucleus	cellular component	IDA[10980613]	283
GO:0005886	plasma membrane	cellular component	IDA[10980613]	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0035335	peptidyl-tyrosine dephosphorylation	biological process	IEA; TAS[2170109]	9
GO:0046627	negative regulation of insulin receptor signaling pathway	biological process	ISS	3
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway	biological process	IEA	3
GO:0042803	protein homodimerization activity	molecular function	IEA	71
GO:0033003	regulation of mast cell activation	biological process	IEA	1
GO:0005737	cytoplasm	cellular component	IDA[10980613]	322
GO:0006470	protein dephosphorylation	biological process	TAS[2170109]	10
GO:0005515	protein binding	molecular function	IPI[10980613]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 9)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PTPRE	KCNB1	NO	in vitro	12615930
PTPRE	PTPRD	YES	in vivo	12376545
PTPRE	GRB2	NO	in vivo	10490839
PTPRE	MAPK1	NO	in vitro	12754301
PTPRE	SRC	NO	in vitro	15845350 , 15522235
PTPRE	KCNA5	NO	in vitro	10921884 , 15588985
PTPRE	MAPK3	NO	in vitro	12754301 , 15588985
PTPRE	PTPRS	NO	in vivo	12376545
PTPRE	YES1	NO	in vitro	14980517 , 15588985

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q25-q26	chr10:104000000-133797422	2 (0/0/2)
10q26	chr10:117300000-133797422	3 (0/1/2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	It showed no evidence for association with SZ.	Negative

Gene relationship with MDD

View in gBrowse

Region: chr10:127907061..128085855 View in gBrowse